Rewiring carbon catabolite repression for microbial cell factory

BMB Reports
Parisutham VinuselviCheol-Min Ghim

Abstract

Carbon catabolite repression (CCR) is a key regulatory system found in most microorganisms that ensures preferential utilization of energy-efficient carbon sources. CCR helps microorganisms obtain a proper balance between their metabolic capacity and the maximum sugar uptake capability. It also constrains the deregulated utilization of a preferred cognate substrate, enabling microorganisms to survive and dominate in natural environments. On the other side of the same coin lies the tenacious bottleneck in microbial production of bioproducts that employs a combination of carbon sources in varied proportion, such as lignocellulose-derived sugar mixtures. Preferential sugar uptake combined with the transcriptional and/or enzymatic exclusion of less preferred sugars turns out one of the major barriers in increasing the yield and productivity of fermentation process. Accumulation of the unused substrate also complicates the downstream processes used to extract the desired product. To overcome this difficulty and to develop tailor-made strains for specific metabolic engineering goals, quantitative and systemic understanding of the molecular interaction map behind CCR is a prerequisite. Here we comparatively review the universal and st...Continue Reading

References

Dec 1, 1996·Applied and Environmental Microbiology·K DeandaS Picataggio
Jul 1, 1996·Research in Microbiology·D N CollierP V Phibbs
Mar 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T InadaH Aiba
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·K KimataH Aiba
Jun 10, 1998·Microbiology and Molecular Biology Reviews : MMBR·J M Gancedo
Mar 24, 1999·Trends in Genetics : TIG·M Johnston
Aug 14, 2001·Applied Microbiology and Biotechnology·N N NicholsR J Bothast
Nov 6, 2001·Applied Microbiology and Biotechnology·V Hernández-MontalvoG Gosset
Oct 31, 2002·Journal of Industrial Microbiology & Biotechnology·B S DienR J Bothast
Jun 6, 2003·The Journal of Biological Chemistry·Pamela K ForemanMichael Ward
Nov 13, 2003·Genome Biology·Ruud GeladéJohan M Thevelein
Jun 24, 2004·Infection and Immunity·Tracy L NicholsonRichard S Stephens
Feb 12, 2005·The Journal of Biological Chemistry·Mingzhu LiuFrederick R Blattner
May 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yi-Heng Percival Zhang, Lee R Lynd
Mar 10, 2006·Microbiology and Molecular Biology Reviews : MMBR·George M Santangelo
Apr 12, 2006·Microbial Cell Factories·Kaisa KarhumaaMarie-F Gorwa-Grauslund
Jul 14, 2006·Biotechnology and Bioengineering·Patrick C CirinoLonnie O Ingram
Dec 13, 2006·Microbiology and Molecular Biology Reviews : MMBR·Josef DeutscherPieter W Postma
Jun 26, 2007·Journal of Molecular Biology·Sven HalbedelJörg Stülke
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Q K BegZ N Oltvai
Sep 4, 2007·Microbes and Infection·Mariela ScorttiJosé A Vázquez-Boland
Mar 25, 2008·Current Opinion in Microbiology·Josef Deutscher
Apr 22, 2008·Applied and Environmental Microbiology·Cong T TrinhFriedrich Srienc
Jul 17, 2008·Nature Reviews. Microbiology·Boris Görke, Jörg Stülke

❮ Previous
Next ❯

Citations

Sep 25, 2015·Biotechnology Progress·Yong Jae KimYong Keun Chang
Dec 19, 2012·Bioresource Technology·Hyun Gyu LimGyoo Yeol Jung
Jan 4, 2018·International Journal of Molecular Sciences·Muhammad AdnanGuodong Lu
Nov 4, 2015·Journal of Bacteriology·Santosh KoiralaChristopher V Rao
May 27, 2014·Applied and Environmental Microbiology·Fengxue XinJianzhong He
Feb 28, 2018·Environmental Science and Pollution Research International·Renato Nallin MontagnolliEderio Dino Bidoia
Mar 25, 2019·Applied and Environmental Microbiology·Alekhya GovindarajuBreah LaSarre
Nov 27, 2019·Cellular and Molecular Life Sciences : CMLS·Heejoon ParkRoss P Carlson
Sep 27, 2018·Biotechnology for Biofuels·Fengxue XinMin Jiang
Sep 23, 2018·BMC Systems Biology·Andreas KremlingHidde de Jong
Feb 11, 2021·Critical Reviews in Biotechnology·Angelo B BañaresWook-Jin Chung
Jul 30, 2021·Microbiological Research·Abhinav Nair, Saurabh Jyoti Sarma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.