Reye syndrome: results of intensive supportive care.

The Journal of Pediatrics
D C DeVivoM W Haymond

Abstract

Thirty-six patients with Reye syndrome were admitted to St. Louis Children's Hospital during a ten-year period from January, 1966, through June, 1975; ten patients (28%) died. Seven (64%) of the ten deaths occurred in the 11 patients admitted between 1966 and 1971, whereas only three (12%) of 25 patients died thereafter. We attribute this reduction in case fatality rate to early diagnosis, recognition of milder cases, and intensive medical support including continuous intravenous infusion of hypertonic glucose, intermittent infusion of hypertonic mannitol, and early elective endotracheal intubation. Analyses of metabolic, hormonal, and blood gas data obtained serially during the acute illness in 16 of these patients provide a basis for a discussion of the pathophysiology of this disorder.

References

Nov 1, 1970·The Journal of Clinical Investigation·J H ThurstonE M Jones
Jul 1, 1973·Anesthesia and Analgesia·E A TalmageJ H Weeks
Aug 1, 1960·The Journal of Clinical Investigation·J B POSNER, F PLUM

❮ Previous
Next ❯

Citations

Mar 1, 1978·Annals of Neurology·M W HaymondD C DeVivo
Sep 1, 1981·Indian Journal of Pediatrics·R H MerchantS V Gharpure
Apr 15, 1976·The New England Journal of Medicine·A L Smith
Oct 3, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Elora Hussain, Douglas Nordli
Aug 1, 1990·Acta Paediatrica Japonica; Overseas Edition·C S ChiN Lin
Apr 1, 1982·Archives of Disease in Childhood·M H BellmanD L Miller
Mar 1, 1984·Archives of Disease in Childhood·J F Glasgow
Apr 1, 1988·Journal of Neurosurgery·G H BarnettJ Romeo
Jun 1, 1976·The Journal of Pediatrics·L Lansky
Aug 1, 1975·The Journal of Pediatrics·B W StechenbergR D Feigin
Dec 1, 1976·The Journal of Pediatrics·J S Haller
Nov 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W R TreemJ B Watkins
May 1, 1977·Pediatric Annals·J C Partin
Jul 1, 1979·Clinical EEG (electroencephalography)·L Ch'ienH Lemmi
Sep 1, 1982·Indian Journal of Pediatrics·A P Sarnaik
Aug 1, 1980·Annals of Neurology·L G Tomasi
Jan 1, 1980·Annals of Neurology·D A Trauner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.