Reye syndrome: treatment by exchange transfusion with special reference to the 1974 epidemic in Cincinnati, Ohio.

The Journal of Pediatrics
R C BoboJ S Partin

Abstract

The treatment of 66 children with Reye syndrome proved by hepatic biopsy or autopsy is described. Prior to the utilization of exchange transfusion early in the course of the disease, our case fatality rate was 100% of nine patients. With early diagnosis and early exchange transfusion, the case fatality rate was reduced to 27% of 44 patients. During the 1974 epidemic of Reye syndrome, 26 children were treated. In 18 children the diagnosis was established by hepatic biopsy; 16 received one or more exchange transfusions. There were no deaths among these 26 patients. In the 1974 epidemic, the national case fatality rate was estimated to be 40%. Exchange transfusion appears to have been an important factor in the reduction of the case fatality rate among our patients.

References

Jan 1, 1975·American Journal of Diseases of Children·J S Haller
Dec 1, 1974·American Journal of Diseases of Children·S Lazoff, A Renschler
Jul 1, 1960·American Journal of Diseases of Children·R HONG, W K SCHUBERT
Dec 1, 1961·Brain : a Journal of Neurology·G LYONR D ADAMS

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Citations

Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·W R GoffP T Rothstein
Feb 1, 1982·Journal of the Neurological Sciences·H J Manz, A R Colon
Jul 1, 1976·The Journal of Pediatrics·R A StraussR A Danielson
Jun 19, 1980·The New England Journal of Medicine·W B HinshawK M Hatch
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E S KangJ F Griffith
Aug 1, 1990·Acta Paediatrica Japonica; Overseas Edition·C S ChiN Lin
Apr 1, 1982·Archives of Disease in Childhood·M H BellmanD L Miller
Mar 1, 1984·Archives of Disease in Childhood·J F Glasgow
May 1, 1977·Pediatric Annals·J C Partin
Jun 22, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·William F Balistreri
Dec 1, 1976·The Journal of Pediatrics·J S Haller
May 1, 1976·The Journal of Pediatrics·C C Linnemann, G M Schiff
Aug 1, 1981·Clinical Pediatrics·D M Volk
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E HeubiW K Schubert
Sep 1, 1976·Hospital Practice·M Davidson

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