Rezafungin (CD101), a next-generation echinocandin: A systematic literature review and assessment of possible place in therapy

Journal of Global Antimicrobial Resistance
Amelia K SofjanKevin W Garey

Abstract

Rezafungin (CD101) is a novel echinocandin currently under development. The purpose of this study was to perform a systematic literature review of published evidence on rezafungin and an antimicrobial stewardship audit of real-world use of echinocandins to determine areas of unmet medical needs and potential places in therapy for rezafungin. The systematic literature review identified 8 peer-reviewed manuscripts and 19 separate abstracts. A stewardship audit was performed on hospitalised patients receiving echinocandins to better understand potential future areas of use for rezafungin. Rezafungin is a cyclic hexapeptide with a lipophilic tail derived from anidulafungin, with a choline moiety at the C5 ornithine position resulting in increased in vitro and in vivo stability compared with other echinocandins. Microbiological data showed similar susceptibility and resistance development between rezafungin and other echinocandins. Rezafungin has a long half-life (80h) and a favourable safety profile that allows for high doses (up to 400mg) given once weekly. A phase 2 study is ongoing. The antimicrobial stewardship audit of echinocandin identified several areas of possible use for rezafungin, including patients receiving daily echi...Continue Reading

Citations

Aug 18, 2018·Journal of Fungi·Ronen Ben-Ami
Sep 26, 2019·Expert Opinion on Drug Metabolism & Toxicology·Jamie JohnThomas J Walsh
Oct 28, 2019·Current Topics in Medicinal Chemistry·Laura Nunes SilvaAndré Luis Souza Dos Santos
Jul 15, 2020·Expert Review of Anti-infective Therapy·Seyed MohammadReza HashemianAli Akbar Velayati
Sep 21, 2019·The Journal of Antimicrobial Chemotherapy·Zoltán TóthLászló Majoros
Dec 4, 2019·Clinical Pharmacology in Drug Development·Shawn FlanaganTaylor Sandison
Mar 24, 2020·Current Fungal Infection Reports·Victoria M StevensTyree H Kiser
Dec 12, 2019·Frontiers in Microbiology·Soraia L LimaJoão N de Almeida Junior
Jul 15, 2020·Expert Opinion on Investigational Drugs·Yidong YuAndreas Beilhack
Dec 4, 2020·Applied Microbiology and Biotechnology·Wolfgang Hüttel
Jan 14, 2021·Future Microbiology·Young Yoon HamGeorge R Thompson
Feb 5, 2021·Expert Opinion on Pharmacotherapy·Liliana ScorzoniEleftherios Mylonakis
Jun 10, 2020·Journal of Pharmaceutical and Biomedical Analysis·B UribeK Gaudin
Oct 23, 2018·Pharmacology & Therapeutics·André Moraes NicolaMaria Sueli Felipe
Apr 5, 2021·Mycopathologia·Amelia BercussonAnand Shah
Jul 17, 2021·Mycopathologia·Grant Waterer
Jul 22, 2020·Journal of Medicinal Chemistry·Wei LiuShengzheng Wang

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