Rezafungin (CD101) demonstrates potent in vitro activity against Aspergillus, including azole-resistant Aspergillus fumigatus isolates and cryptic species

The Journal of Antimicrobial Chemotherapy
Nathan P WiederholdKen Bartizal

Abstract

Rezafungin is an investigational echinocandin under development for the treatment and prevention of invasive fungal infections, with a long half-life in humans (∼130 h) and potent in vitro activity against Aspergillus spp. Our objective was to further evaluate its activity against Aspergillus fumigatus isolates, including azole-resistant isolates and cryptic Aspergillus spp. Clinical isolates of Aspergillus were used, including 15 WT and 31 azole-resistant A. fumigatus, 11 Aspergillus lentulus, 5 each of Aspergillus thermomutatus and Aspergillus udagawae and 11 Aspergillus calidoustus. Minimum effective concentrations (MECs) and MICs of rezafungin, caspofungin, micafungin, posaconazole and voriconazole were determined by CLSI M38-A2 broth microdilution. Differences in geometric mean (GM) MEC/MIC values were assessed for significance by ANOVA. Rezafungin GM MECs for A. fumigatus were 0.024 and 0.043 mg/L for WT and azole-resistant isolates, respectively. Rezafungin was also active against cryptic species, including A. lentulus (0.016 mg/L), A. calidoustus (0.044 mg/L), A. thermomutatus (MEC range ≤0.015-0.25 mg/L) and A. udagawae (≤0.015-0.03 mg/L). This activity was similar to that of caspofungin and micafungin with the excepti...Continue Reading

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Citations

May 30, 2019·Antimicrobial Agents and Chemotherapy·Marion AruannoFrédéric Lamoth
Aug 14, 2019·Antimicrobial Agents and Chemotherapy·Nathan P WiederholdThomas F Patterson
Oct 28, 2019·Current Topics in Medicinal Chemistry·Laura Nunes SilvaAndré Luis Souza Dos Santos
Apr 30, 2020·Investigative Ophthalmology & Visual Science·Lu ZhanGuiqiu Zhao
Feb 27, 2020·Open Forum Infectious Diseases·Adriana M RauseoAndrej Spec
Dec 12, 2019·Frontiers in Microbiology·Soraia L LimaJoão N de Almeida Junior
Jul 1, 2020·Journal of Fungi·Amir ArastehfarMartin Hoenigl
Jul 14, 2020·Current Opinion in Infectious Diseases·Nathan P Wiederhold, Paul E Verweij
Jan 30, 2020·Frontiers in Microbiology·Rocio Garcia-RubioNuria Trevijano-Contador
Jan 14, 2021·Future Microbiology·Young Yoon HamGeorge R Thompson
Jun 3, 2021·Current Fungal Infection Reports·Garret T Seiler, Luis Ostrosky-Zeichner
May 27, 2021·Studies in Mycology·A ArastehfarM Hoenigl
Jul 8, 2021·Expert Opinion on Pharmacotherapy·Adam G Stewart, David L Paterson
Jul 31, 2021·Expert Review of Anti-infective Therapy·Daniel Echeverria-EsnalSantiago Grau
Oct 19, 2021·Antimicrobial Agents and Chemotherapy·Voon OngShawn Flanagan

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