PMID: 8600444Mar 1, 1996Paper

RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom

Nucleic Acids Research
P EmeryW Reith

Abstract

Until recently, the RFX family of DNA binding proteins consisted exclusively of four mammalian members (RFX1-RFX4) characterized by a novel highly conserved DNA binding domain. Strong conservation of this DNA binding domain precluded a precise definition of the motif required for DNA binding. In addition, the biological systems in which these RFX proteins are implicated remained obscure. The recent identification of four new RFX genes has now shed light on the evolutionary conservation of the RFX family, contributed greatly to a detailed characterization of the RFX DNA binding motif, and provided clear evidence for the function of some of the RFX proteins. RFX proteins have been conserved throughout evolution in a wide variety of species, including Saccharomyces cerevisiae, Schizosaccharomyces pombe, Caenorhabditis elegans, mouse and man. The characteristic RFX DNA binding motif has been recruited into otherwise very divergent regulatory factors functioning in a diverse spectrum of unrelated systems, including regulation of the mitotic cell cycle in fission yeast, the control of the immune response in mammals, and infection by human hepatitis B virus.

References

May 1, 1992·Molecular Endocrinology·H DotzlawL C Murphy
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman

❮ Previous
Next ❯

Citations

Jun 14, 2005·Phytochemistry·Axel A BrakhagePetra Spröte
Jun 1, 2005·Genomics·Deborah WilskerElizabeth Moran
Feb 1, 1997·Current Opinion in Immunology·J M Boss
Feb 12, 2010·Nature·Stuart B SmithMichael S German
Nov 23, 2012·Biologie aujourd'hui·Julie JerberBénédicte Durand
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Brian P PiaseckiPeter Swoboda
Mar 2, 2010·The Journal of Biological Chemistry·Yi-Chao HsuIng-Ming Chiu
Mar 25, 2005·The Journal of Biological Chemistry·Pritam SenguptaBarbara D Smith
Aug 2, 2000·The EMBO Journal·B Li, J C Reese
Jun 25, 2008·Molecular Biology and Evolution·Ya-Wen ChangWen-Hsiung Li
Jun 20, 1998·Nucleic Acids Research·F CornilleW Reith
Oct 21, 2004·Nucleic Acids Research·Kyoko OtsukiMasamitsu Yamaguchi
Jan 11, 2005·Nucleic Acids Research·Antonia PatsialouElizabeth Moran
Mar 17, 2006·Nucleic Acids Research·Jinshui FanMyriam Gorospe
Aug 19, 2005·Molecular and Cellular Biology·Zhengjian Zhang, Joseph C Reese
Mar 13, 2001·Annual Review of Immunology·W Reith, B Mach
Dec 17, 2009·BMC Developmental Biology·Gary C HorvathW Stephen Kistler
Aug 5, 2008·BMC Evolutionary Biology·Syed AftabNansheng Chen
Feb 9, 2016·Scientific Reports·Yujian WuChunsheng Han
Jul 20, 2010·Biochimica Et Biophysica Acta·Madhumita ChakrabortyAbhijit Chakrabarti
May 12, 2010·Biophysical Chemistry·Madhumita ChakrabortyAbhijit Chakrabarti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.