RGD-conjugated albumin nanoparticles as a novel delivery vehicle in pancreatic cancer therapy

Cancer Biology & Therapy
Shunrong JiXianjun Yu

Abstract

Integrin αvβ3 receptor is expressed on several types of cancer cells, including pancreatic cancer cells, and plays an important role in tumor growth and metastasis. The ability to target the integrin αvβ3 receptor on cancer cells increases the efficacy of targeted therapy and reduces the side effects. The aim of this study is to develop a novel arginine-glycine-aspartic acid (RGD) peptide -conjugated albumin nanoparticle to enhance the intracellular uptake of anticancer drug into the pancreatic cancer cells through receptor-mediated endocytosis. In the cellular uptake studies, the fluorescent signal of RGD-conjugated BSANPs in BxPC3 cells was higher than that of BSANPs without RGD conjugation as determined by fluorescence spectrophotometer. We also found that BSANPs bound to BxPC3 cells in a time- and concentration-dependent manner. The uptake of RGD-conjugated BSANPs by pancreatic cancer cells was inhibited by an excess amount of free RGD peptide, indicating that the binding and/or uptake were mediated by the αvβ3 receptor. Furthermore, the nanoparticles were found to be located close to the nuclei by using laser scanning confocal microscopy. Besides, no significant in vitro cytotoxicity was observed as measured with MTT assay...Continue Reading

References

Aug 1, 1995·Gynecologic Oncology·S A CannistraJ DiCarlo
Jan 1, 1997·Journal of Colloid and Interface Science·R KurratJ J Ramsden
Feb 24, 1999·Nature·C D BuckleyM Salmon
Dec 22, 1999·International Journal of Pharmaceutics·C WeberK Langer
Aug 17, 2000·Biochemical and Biophysical Research Communications·I C KangK H Chung
Nov 1, 2000·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·E L Gelamo, M Tabak
Feb 24, 2001·Cell Biology and Toxicology·C D AnuradhaS Hirano
Jul 20, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Andries M BergmanGodefridus J Peters
Aug 10, 2002·Annals of Surgery·Markus SchäferPierre-Alain Clavien
Mar 31, 2004·Lancet·Donghui LiJames L Abbruzzese
Nov 16, 2004·International Journal of Pharmaceutics·Liangke ZhangYi Lu
Mar 2, 2005·Journal of the American College of Surgeons·Shane E HollowayJason B Fleming
Apr 6, 2006·Cancer Causes & Control : CCC·Rosemary D CressElizabeth A Holly
May 23, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Stefan LinderBo Nilsson
Dec 19, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Kulrut BorrirukwanitErik W Thompson
May 8, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ri CuiKazuhisa Takahashi
May 19, 2007·The Journal of Pharmacology and Experimental Therapeutics·Shi-Lin DuJi-Yao Wang
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
May 14, 2008·Current Pharmaceutical Design·L Harivardhan Reddy, Patrick Couvreur
May 30, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Jing ZhangCheng Sheng Liu
Jul 9, 2008·Translational Oncology·Meredith A MorganTheodore S Lawrence
Sep 23, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Karsten UlbrichJörg Kreuter

❮ Previous
Next ❯

Citations

Aug 27, 2014·BioMed Research International·Henricus J M HandgraafJ Sven D Mieog
Jul 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sabrina ValettiPatrick Couvreur
Oct 23, 2014·Therapeutic Delivery·Paul ZarogoulidisKonstantinos Zarogoulidis
Dec 19, 2014·Expert Opinion on Drug Delivery·Darrell Sleep
Nov 28, 2015·Journal of Materials Science. Materials in Medicine·Xinzhe Yu, Chen Jin
Nov 26, 2015·The EPMA Journal·Ana C FonsecaJorge F J Coelho
Sep 27, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vidya GanapathyCharles M Roth
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·L R JaidevSwaminathan Sethuraman
Jul 15, 2015·International Journal of Pharmaceutics·Ravindra Dhar DubeyPrem N Gupta
Apr 18, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Md Lutful AminSeong Soo A An
Aug 23, 2018·Cancer Biotherapy & Radiopharmaceuticals·Guanglei FanYiwei Wu
Aug 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dunja SobotPatrick Couvreur
May 20, 2020·Therapeutic Advances in Medical Oncology·Tianqi SuJiannan Li
Sep 1, 2019·International Journal of Molecular Sciences·Keiko YamakawaYoko Matsuda
Mar 30, 2020·Cancer Research·Christopher GromischMark W Grinstaff
May 22, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Zhengze LuQin He
Dec 31, 2021·Journal of Medicinal Chemistry·Theodora ChatzisideriVasiliki Sarli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.