RGD-containing peptides trigger apoptosis in glomerular mesangial cells of adult human kidneys

Biochemical and Biophysical Research Communications
X ChenL Yu

Abstract

Substantial evidence was given that different Arg-Gly-Asp (RGD)-containing peptides, linear Arg-Gly-Asp-Ser (RGDS) and cyclic Arg-Gly-Asp-Phe (RGDF), which are sequences present in fibronectin and vitronectin and which can bind alpha5beta1 and alpha(v)beta3 integrins, respectively, both induced apoptosis and expression of interleukin-1beta-converting enzyme (ICE) in cultured glomerular mesangial cells from adult human kidneys, with consistent apoptosis features appearing as nuclei condensation and fragmentation, internucleosomal DNA fragmentation, and DNA content decrease. These results indicated that both fibronectin and vitronectin may be important in the survival of human glomerular mesangial cells and that stable cyclic RGD(D)FV peptide may be a candidate to be used for regulating apoptosis in vivo.

References

Feb 28, 1986·Cell·E Ruoslahti, M D Pierschbacher
May 20, 1994·Cell·E Ruoslahti, J C Reed
Apr 1, 1996·Kidney International·S González-CuadradoA Ortiz

❮ Previous
Next ❯

Citations

Jan 10, 2003·Nucleic Acids Research·Angelo M FacchianoFrancesco Facchiano
Nov 4, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kerstin AmannHarald O Schöcklmann
Nov 26, 2009·Molecular Nutrition & Food Research·Elvira Gonzalez de MejiaVermont P Dia
Jul 30, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Elisabeth GarangerJean-Luc Coll
Jun 29, 2013·International Journal of Molecular Sciences·Fen WangTian Xie
Oct 11, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Baptiste Michel
Dec 7, 2018·ChemMedChem·Fatima HamdanSaeed Balalaie
Jan 29, 2005·Journal of the American Society of Nephrology : JASN·Di WuJianZhong Wang
Feb 26, 2004·Blood·Maria Simona AguzziAntonio Facchiano
Mar 22, 2013·American Journal of Physiology. Renal Physiology·Nozomu KamiuraKeiichi Hishikawa
Dec 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·S CastelM Reina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis