Abstract
Substantial evidence was given that different Arg-Gly-Asp (RGD)-containing peptides, linear Arg-Gly-Asp-Ser (RGDS) and cyclic Arg-Gly-Asp-Phe (RGDF), which are sequences present in fibronectin and vitronectin and which can bind alpha5beta1 and alpha(v)beta3 integrins, respectively, both induced apoptosis and expression of interleukin-1beta-converting enzyme (ICE) in cultured glomerular mesangial cells from adult human kidneys, with consistent apoptosis features appearing as nuclei condensation and fragmentation, internucleosomal DNA fragmentation, and DNA content decrease. These results indicated that both fibronectin and vitronectin may be important in the survival of human glomerular mesangial cells and that stable cyclic RGD(D)FV peptide may be a candidate to be used for regulating apoptosis in vivo.
References
Feb 28, 1986·Cell·E Ruoslahti, M D Pierschbacher
May 20, 1994·Cell·E Ruoslahti, J C Reed
Apr 1, 1996·Kidney International·S González-CuadradoA Ortiz
Citations
May 23, 2001·The Biochemical Journal·J JeongE S Oh
Oct 3, 1999·Kidney International·Q XuQ Cheng
Jan 10, 2003·Nucleic Acids Research·Angelo M FacchianoFrancesco Facchiano
Nov 4, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kerstin AmannHarald O Schöcklmann
Jun 18, 2014·PloS One·Warren B NothnickMitchell J Weiss
Jun 29, 2002·Neuroscience·X BiG Lynch
Nov 26, 2009·Molecular Nutrition & Food Research·Elvira Gonzalez de MejiaVermont P Dia
Oct 14, 2000·Acta Physiologica Hungarica·B AntusL Rosivall
May 23, 2012·Immunity·Hye-Kyoung JunBong-Kyu Choi
Jul 30, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Elisabeth GarangerJean-Luc Coll
Jun 29, 2013·International Journal of Molecular Sciences·Fen WangTian Xie
Oct 11, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Baptiste Michel
Dec 7, 2018·ChemMedChem·Fatima HamdanSaeed Balalaie
Jan 29, 2005·Journal of the American Society of Nephrology : JASN·Di WuJianZhong Wang
Feb 26, 2004·Blood·Maria Simona AguzziAntonio Facchiano
Mar 22, 2013·American Journal of Physiology. Renal Physiology·Nozomu KamiuraKeiichi Hishikawa
Dec 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·S CastelM Reina
Oct 18, 2000·Biochemical and Biophysical Research Communications·V Moreno-ManzanoM Kitamura
Jun 26, 2002·Kidney International·Hongli LinZhiheng Yu
Jan 24, 2004·Biomaterials·Jin Woo LeeSoo Bong Hahn