RGD decoration of PEGylated polyester nanocapsules of perfluorooctyl bromide for tumor imaging: influence of pre or post-functionalization on capsule morphology

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Odile DiouNicolas Tsapis

Abstract

PEGylated polyester nanocapsules of perfluorooctyl bromide (PFOB) were surface-decorated with a RGD (arginine-glycine-aspartic acid) peptide by either pre-functionalization or post-functionalization strategies using carbodiimide-assisted chemistry. Both strategies allowed successful linkage of RGD at the surface of nanocapsules with up to 600-950 peptide units per nanocapsule without modifying the encapsulation efficacy of PFOB used as the (19)F MRI imaging moiety. Cryo-Transmission Electron Microscopy images evidence that slight changes of the polymer used to form the capsule shell strongly influence nanocapsule morphology. While, the use of copolymer blends induces the formation of acorn morphologies, PLA-b-PEG-COOH leads to elongated and "tears of wine"-like nanoconstructs. In vivo evaluation in mice bearing CT26 tumors by (19)F MRI reveals no significant difference of accumulation between PEGylated and RGD-decorated nanocapsules obtained by the post-functionalization approach (highest RGD density/capsule).

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Citations

Nov 4, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohamadreza AminTimo L M Ten Hagen
Nov 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Benjamin NotteletJean Coudane
May 3, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Hieu Vu-QuangJørgen Kjems
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Sep 7, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tanguy BoissenotNicolas Tsapis
Oct 9, 2018·Advanced Healthcare Materials·Mohamed F AttiaFrank Alexis
Jan 31, 2019·Journal of Cellular Physiology·Maryam Ebrahimi NikBizhan Malaekeh-Nikouei
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Oct 17, 2020·International Journal of Nanomedicine·Lina WuXilin Sun
Feb 8, 2020·Biomacromolecules·Sjoerd J RijpkemaDaniela A Wilson

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