RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Maciej SalagaJakub Fichna

Abstract

Regulators of G protein signaling (RGS) proteins provide timely termination of G protein-coupled receptor (GPCR) responses. Serving as a central control point in GPCR signaling cascades, RGS proteins are promising targets for drug development. In this review, we discuss the involvement of RGS proteins in the pathophysiology of the gastrointestinal inflammation and their potential to become a target for anti-inflammatory drugs. Specifically, we evaluate the emerging evidence for modulation of selected receptor families: opioid, cannabinoid and serotonin by RGS proteins. We discuss how the regulation of RGS protein level and activity may modulate immunological pathways involved in the development of intestinal inflammation. Finally, we propose that RGS proteins may serve as a prognostic factor for survival rate in colorectal cancer. The ideas introduced in this review set a novel conceptual framework for the utilization of RGS proteins in the treatment of gastrointestinal inflammation, a growing major concern worldwide.

References

Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·B E SnowD P Siderovski
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C MoratzJ H Kehrl
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·A J Oliveira-Dos-SantosJ M Penninger
Feb 24, 2001·The European Journal of Neuroscience·J GarzónP Sánchez-Blázquez
Jul 13, 2002·The Journal of Comparative Neurology·Angela A CouttsSharon Anavi-Goffer
Mar 7, 2003·Journal of Neuroimmunology·Nilka TomassiniHorace H Loh
Jun 20, 2003·Neuropharmacology·Pilar Sánchez-BlázquezJavier Garzón
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric LippertKirk M Druey
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Javier GarzónPilar Sánchez-Blázquez
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Venetia ZachariouEric J Nestler
Mar 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Javier GarzónPilar Sánchez-Blázquez
Apr 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Javier GarzónPilar Sánchez-Blázquez
Oct 26, 2005·Current Biology : CB·Thomas M Wilkie, Lisa Kinch
Jan 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giuseppe D'ArgenioVincenzo Di Marzo
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mohamad BouhamdanRodrigo Andrade
Apr 25, 2006·Chemical Biology & Drug Design·Rebecca A RoofRichard R Neubig
May 10, 2006·PLoS Genetics·Kevin FitzgeraldRachel M Kindt
May 12, 2006·Seminars in Cell & Developmental Biology·Gary B Willars
Aug 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·María Rodríguez-MuñozJavier Garzón
Jul 21, 2007·The Journal of Endocrinology·Damian G RomeroElise P Gomez-Sanchez
Aug 30, 2007·Journal of Neurochemistry·Kassi PsifogeorgouVenetia Zachariou
May 22, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Martin A StorrKeith A Sharkey
Jul 29, 2008·Circulation Research·Carlo CifelliScott P Heximer
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geetanjali BansalKirk M Druey
Aug 27, 2009·Gastroenterology·Jean-Eric GhiaWaliul I Khan
Sep 18, 2009·Annals of Surgical Oncology·Norikatsu MiyoshiMasaki Mori
Feb 2, 2010·Pharmacology & Therapeutics·Angelo A Izzo, Keith A Sharkey
Apr 7, 2010·Cellular Signalling·Nan SethakornNickolai O Dulin
Jun 24, 2010·Molecular Pharmacology·Levi L BlazerRichard R Neubig
Aug 10, 2010·Progress in Molecular Biology and Translational Science·Benita SjögrenRichard R Neubig
Sep 25, 2010·Circulation Research·Jianqi YangRory A Fisher

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