RGS2 C1114G polymorphism and body weight gain in hypertensive patients

Metabolism: Clinical and Experimental
Michelangelo SartoriHARVEST Group

Abstract

RGS2 is a negative regulator of Galpha protein signaling and promotes adipocyte differentiation. Recently, we described a polymorphism at the C1114G locus with the G allele associated with hypertension in a cross-sectional study. The aim of the present study was to assess whether the RGS2 C1114G is predictive of overweight in young subjects with grade I hypertension. We genotyped at the RGS2 C1114G locus 406 (male, n = 294; female, n = 112) white hypertensive subjects (age, 33 +/- 9 years) never treated for hypertension and at low cardiovascular risk. Median follow-up was 7.85 years. At baseline, male patients carrying the RGS2 1114G allele had higher body mass index (BMI) than patients with CC genotype (26.1 +/- 0.3 vs 25.3 +/- 0.3 kg/m2, P < .05). The frequency of male patients with BMI > or = 25 was similar between the patients with G allele and those with CC genotype (55.1% vs 47.8%, P = not significant). No significant difference between the 2 groups was observed with regard to physical activity, blood pressure, and heart rate. At the end of follow-up, BMI was higher in male patients with G allele compared with patients with CC genotype (26.8 +/- 0.3 vs 25.8 +/- 0.2 kg/m2, P < .01); and the frequency of male patients with ...Continue Reading

References

Oct 1, 1989·Cardiovascular Drugs and Therapy·J R Hampton
Jan 1, 1997·Annual Review of Biochemistry·S R Sprang
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·S P HeximerJ R Hepler
Jan 27, 1999·Biochemical and Biophysical Research Communications·M ImagawaT Nishihara
Nov 24, 1999·The Journal of Biological Chemistry·S P HeximerK J Blumer
Mar 22, 2002·The International Journal of Biochemistry & Cell Biology·John H Kehrl, Srikumar Sinnarajah
Feb 18, 2003·The Journal of Clinical Investigation·Scott P HeximerKendall J Blumer
Mar 30, 2004·Diabetes·Carl D LangefeldUNKNOWN Insulin Resistance Atherosclerosis Study Family Study
Sep 15, 2004·European Journal of Endocrinology·Markus EszlingerRalf Paschke
Apr 19, 2005·Obesity Research·Louis PérusseClaude Bouchard
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Apr 29, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dominique Langin
Sep 22, 2006·Human Molecular Genetics·Andrew J WalleyPhilippe Froguel
Nov 11, 2006·BMJ : British Medical Journal·Sarah H Wild, Christopher D Byrne

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Citations

Dec 2, 2011·PloS One·Jeffrey L WaughAbraham Kovoor
May 28, 2011·Archives of Biochemistry and Biophysics·Guillaume Bastin, Scott P Heximer
Jan 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian YaoXianghuo He
Apr 10, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M SartoriG Palareti
Aug 26, 2016·BMC Genetics·Tiina KarppanenHannele Laivuori
Dec 14, 2018·The Journal of Biological Chemistry·Laura J SharpeAndrew J Brown
Oct 14, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Nicola A ScottAndrew J Brown

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