PMID: 9556034Apr 29, 1998Paper

RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum

Journal of Neuroscience Research
E A ThomasJ G Sutcliffe

Abstract

A clone of the regulator of G-protein signalling, RGS9, was isolated from a rat striatum-minus-cerebellum-minus-hippocampus subtracted library generated by directional tag polymerase chain reaction subtraction. The full-length cDNA clone encodes a 444 amino acid protein containing an 118 amino acid RGS domain, which corresponds to an evolutionarily conserved domain that is present in all members of the RGS family of proteins. Outside of the homology domain, RGS9 shows more extended similarity to human RGS6 and RGS7, rat RGS12, and the C. elegans protein EGL-10. During embryonic and early postnatal stages of development, two RGS9 transcripts of approximately 1.4 Kb and 1.8 Kb were detected in whole brain. After postnatal day 10, accumulation of the larger transcript increased progressively until adulthood at the expense of the smaller transcript, which was undetectable in the adult. In adult rat brain, the 1.8-Kb RGS9 transcript was detected in the striatum but not in other brain regions or peripheral tissues. In situ hybridization in rat and mouse demonstrates that RGS9 mRNA is expressed predominantly in medium-sized, spiny neurons of the neostriatum and in neurons of the nucleus accumbens and olfactory tubercle. Relatively str...Continue Reading

Citations

Mar 26, 2014·PloS One·Kathy BusseJohannes Schwarz
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·B E SnowD P Siderovski
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·K LevayV Z Slepak
Nov 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Theresa M Cabrera-VeraHeidi E Hamm
Apr 1, 2009·Molecular and Cellular Biology·Garret R AndersonKirill A Martemyanov
Jun 13, 2009·Cell Biochemistry and Biophysics·Garret R AndersonKirill A Martemyanov
Jun 19, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deb Kumar MojumderTheodore G Wensel
Nov 10, 2005·Science's STKE : Signal Transduction Knowledge Environment·Dorit Ron, Rachel Jurd
Dec 19, 2006·Journal of Molecular Biology·Guo-Xi Xie, Pamela Pierce Palmer
Jan 13, 2006·Journal of Neurochemistry·Paula A DesplatsElizabeth A Thomas
Dec 13, 2007·Brain Research·Jacqueline BlundellCraig M Powell
Sep 13, 2005·Brain Research. Developmental Brain Research·Ki Jun KimPamela Pierce Palmer
Sep 21, 2007·Biochemical Pharmacology·Shelley B HooksVenetia Zachariou
Feb 27, 2010·Progress in Neurobiology·Mario Herrera-MarschitzUrban Ungerstedt
Feb 2, 2017·Neuroscience and Biobehavioral Reviews·Esther A R NibbelingDineke S Verbeek
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·L De VriesM G Farquhar
Sep 1, 1999·Journal of Neuroscience Research·J D FalkJ G Sutcliffe
Dec 2, 2011·PloS One·Jeffrey L WaughAbraham Kovoor
Sep 20, 2006·Journal of Neuroscience Research·Elizabeth A Thomas
Jun 13, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ying-Jay LiouI-Ching Lai
Mar 6, 2010·Annals of the New York Academy of Sciences·John Traynor
Aug 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Javier GarzónPilar Sánchez-Blázquez
Feb 6, 2020·Molecular Pharmacology·Katelin E Ahlers-DannenRory A Fisher
May 19, 2001·Molecular and Cellular Neurosciences·E M Norlin, A Berghard
Sep 10, 1998·Biochemical and Biophysical Research Communications·J L CabreraV Z Slepak
Jun 24, 2003·Neuron·Kirill A MartemyanovVadim Y Arshavsky
Oct 22, 2008·Brain Research·Laura M HarrisonDavid N Ruskin
Dec 2, 2008·Trends in Pharmacological Sciences·Muralidharan JayaramanKendall J Blumer

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