Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes

Journal of the American Chemical Society
Fei YeTobias Ritter

Abstract

We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance. The hydrocyanation reaction employs acetone cyanohydrin as a practical alternative to HCN gas.

References

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Citations

Jul 12, 2018·Angewandte Chemie·Xi Wang, Armido Studer
Sep 26, 2019·Chemistry : a European Journal·David TejedorFernando García-Tellado
Dec 17, 2019·Chemical Communications : Chem Comm·Tang-Lin LiuYun-Gui Peng
Apr 3, 2020·Chemistry : a European Journal·Feilong SunXianjie Fang
May 21, 2020·Chemical Communications : Chem Comm·Feilong SunXianjie Fang
May 8, 2019·Chemical & Pharmaceutical Bulletin·Shigeru Arai
Dec 18, 2019·Organic & Biomolecular Chemistry·Hongru ZhangKaiwu Dong
Aug 6, 2020·International Journal of Molecular Sciences·Jacek MalinowskiJoanna Drzeżdżon
Jan 19, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Dandan JiangLili Zhao
Jun 13, 2018·Journal of the American Chemical Society·De-Wei GaoKeary M Engle
May 12, 2020·Organic Letters·Nils L FryeArmido Studer
Oct 12, 2018·Organic Letters·Wen-Wen ZhangBi-Jie Li
Oct 24, 2018·Organic Letters·Ji-Shu ZhangLi-Biao Han
Dec 27, 2019·The Journal of Organic Chemistry·Yoshiyuki TakahashiMotoi Kawatsura
Jun 2, 2020·Journal of the American Chemical Society·Benjamin N BhawalBill Morandi
Jan 9, 2020·Organic Letters·Jinguo LongXianjie Fang

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