RH genotype matching for transfusion support in sickle cell disease.

Blood
Stella T ChouConnie M Westhoff

Abstract

Rh alloimmunization remains a challenge for patients with sickle cell disease (SCD) despite transfusion of serologic Rh C, E, and K antigen-matched red cells. Inheritance of altered RH alleles contributes to the prevalence of Rh antibodies after blood transfusion in patients with SCD and explains approximately one-third of cases. The remainder seem to be stimulated by altered Rh proteins on African American donor red cells. Matching patients with donors on the basis of RH genotype may mitigate Rh alloimmunization, but the feasibility and resources required are not known. We compared RH allele frequencies between patients with SCD (n = 857) and African American donors (n = 587) and showed that RH allele frequencies are similar. Overall, 29% of RHD and 53% of RHCE alleles are altered in patients and African American donors. We modeled RH genotype matching compared with serologic Rh D, C, and E, along with K antigen matching, and found that approximately twice the number of African American donors would be required for RH genotype vs Rh serologic matching at our institution. We demonstrated that African American donor recruitment is necessary to maintain an adequate supply of C-, E-, and K-negative donor units to avoid depleting t...Continue Reading

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References

Aug 29, 2006·Transfusion·Willy A FlegelMarilyn K Moulds
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Citations

Feb 2, 2019·British Journal of Haematology·Catherine A HylandElizna M Schoeman
Aug 14, 2019·Transfusion·Carla L DinardoUNKNOWN NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III
Feb 28, 2019·Blood·Connie M Westhoff
Feb 28, 2019·Blood·Christopher A Tormey, Jeanne E Hendrickson
Sep 7, 2019·Current Opinion in Hematology·Celina MontemayorMargaret A Keller
Nov 24, 2019·Transfusion·Nancy L Van BurenConnie M Westhoff
Jan 22, 2020·British Journal of Haematology·Sara TrompeterUNKNOWN Transfusion Task Force of the British Society of Haematology Guidelines Committee
Oct 28, 2019·Annals of Laboratory Medicine·Raisa I Balbuena-MerleConsuelo Climent-Peris
Sep 15, 2018·Blood·Jeanne E Hendrickson, Christopher A Tormey
Jun 7, 2019·British Journal of Haematology·Sanne M MeindertsTimo K van den Berg
Mar 7, 2020·Transfusion·Mathew R P SapianoSridhar V Basavaraju
Jun 9, 2020·Frontiers in Physiology·Gabriel Salinas Cisneros, Swee L Thein
Jan 27, 2021·Clinics in Laboratory Medicine·Yan Zheng, Stella T Chou
Jan 17, 2021·Blood Reviews·J J GerritsmaUNKNOWN SCORE consortium
Dec 15, 2019·Seminars in Hematology·Jamal H Carter, Willy A Flegel
Sep 28, 2021·Blood Advances·Sindy N Escobar Alvarez, Elizabeth R Myers
Dec 11, 2021·Hematology·France PirenneAnoosha Habibi

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