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Rh genotyping: avoiding false-negative and false-positive results among individuals of African ancestry

American Journal of Hematology

Jan 1, 2002

G C EkmanMartin J Hessner

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Abstract

High homology, variant alleles, and silent alleles have made the development of completely reliable genotyping assays for the RHD and RHC alleles difficult. An RHD pseudogene (RHDPsi) possessing a 37-bp insertion within exon 4 is common among serologically RhD-negative individuals of Af...read more

Mentioned in this Paper

False Positive Reactions
Genetic Equilibrium
Homologous Gene
Oligonucleotide Primers
Serotyping
Lymphocyte Subtyping
Genetic Polymorphism
Rh Sensitization
Flank (Surface Region)
African Continental Ancestry Group
Paper Details
References
  • References20
  • Citations7
12

Rh genotyping: avoiding false-negative and false-positive results among individuals of African ancestry

American Journal of Hematology

Jan 1, 2002

G C EkmanMartin J Hessner

PMID: 11835329

DOI: 10.1002/ajh.10013

Abstract

High homology, variant alleles, and silent alleles have made the development of completely reliable genotyping assays for the RHD and RHC alleles difficult. An RHD pseudogene (RHDPsi) possessing a 37-bp insertion within exon 4 is common among serologically RhD-negative individuals of Af...read more

Mentioned in this Paper

False Positive Reactions
Genetic Equilibrium
Homologous Gene
Oligonucleotide Primers
Serotyping

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Paper Details
References
  • References20
  • Citations7
12

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