PMID: 15227745Jul 1, 2004Paper

Rhabdoid cholangiocarcinoma: a variant of cholangiocarcinoma with aggressive behavior

Yonsei Medical Journal
Beom Jin LimYoung Nyun Park

Abstract

A rhabdoid cholangiocarcinoma is a very rare variant of sarcomatous cholangiocarcinomas. Here, we report a vimentin positive cholangiocarcinoma showing rhabdoid features in the entire tumor, with a very aggressive behavior. A 41-year-old woman was admitted to our hospital due to a huge hepatic mass. The resected liver revealed a 17 x 15 cm sized solid mass with extensive necrosis and an infiltrative border. On microscopic examination, the entire tumor was composed of loosely cohesive round to polygonal cells, with rhabdoid features having abundant eosinophilic glassy cytoplasm and eccentrically located vesicular nuclei. Some tumor cells contained intracytoplasmic mucin vacuoles, but definite areas of glandular differentiation or spindle cell were not found. Immunohistochemical staining showed a diffuse strong positive reaction to pan-cytokeratin and vimentin, and focal positivity for the carcinoembryonic antigen. Other immunohistochemical stainings for cytokeratin 7, cytokeratin 20, S-100 protein, HMB-45, desmin, alpha-smooth muscle actin, c-kit, CD34, alpha-fetoprotein, anti-hepatocyte antigen, chromogranin and synaptophysin were all negative. After two months, the patient developed a local recurrence along the resection margi...Continue Reading

Citations

Aug 21, 2013·Pathology International·Isamu SuganoYasuo Ishida
Oct 13, 2006·Virchows Archiv : an International Journal of Pathology·Katsuaki SatoShogo Katsuda
Mar 1, 2019·Medicine·Ning ZhangXiaodong He
Dec 9, 2010·European Journal of Gastroenterology & Hepatology·Elodie SibileauChristophe Aubé
Apr 7, 2011·International Neurourology Journal·Seung-Jin MoonBo Youl Choi
Feb 19, 2019·World Journal of Gastroenterology : WJG·Dong Kyun KimYang Hyun Baek
Jan 24, 2020·World Journal of Clinical Cases·Yan WangXiang-Ming Fang
Dec 28, 2021·International Journal of Surgical Pathology·Hiroshi MinatoHirotaka Kitamura

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