Rhabdomyolysis and hypoxia associated with prolonged propofol infusion in children

Neurology
J P Hanna, M L Ramundo

Abstract

Propofol, a new anesthetic, is now used more commonly to sedate patients in the intensive care unit. Propofol's rapid elimination has popularized its use to induce and maintain hypnosis in patients with refractory status epilepticus. It is also associated with occasional severe metabolic acidosis and hypoxia of indeterminate cause in children. We report a child and an adolescent who developed severe metabolic acidosis, progressive hypoxia, and rhabdomyolysis during maintenance infusion of propofol for the treatment of refractory status epilepticus. We suggest that propofol should not be used for prolonged sedation in children until its safety can be ensured.

References

Jul 4, 1992·BMJ : British Medical Journal·P J Baxter
Jul 1, 1995·Chest·U B Prakash
Jan 1, 1994·Critical Care Medicine·R J Battafarano, D L Dunn

❮ Previous
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Citations

Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J M Pellock, L D Morton
Mar 1, 2002·Muscle & Nerve·Jason D WarrenPhilip D Thompson
Sep 28, 2004·Der Anaesthesist·J Motsch, J Roggenbach
Jun 23, 2006·Intensive Care Medicine·Ilkka ParviainenEsko Ruokonen
Jun 5, 2002·Current Neurology and Neuroscience Reports·Lawrence J Hirsch, Jan Claassen
Dec 4, 2008·Neurocritical Care·Heidi SmithPanayiotis Varelas
May 19, 2001·Neurologic Clinics·B J Smith
Sep 27, 2002·Anesthesiology Clinics of North America·Harvey K Rosenbaum, Jordan D Miller
Dec 4, 1998·Paediatric Anaesthesia·R J Bray
Jan 22, 2003·Paediatric Anaesthesia·Onur OzlüTurgay Ocal
Aug 31, 2000·Critical Care Medicine·N D PerrierM J Murray
Sep 10, 2003·Journal of Pediatric Gastroenterology and Nutrition·Ying-Tai TaiYao-Jong Yang
Jul 9, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P David AdelsonUNKNOWN World Federation of Pediatric Intensive and Critical Care Societies
Nov 12, 2003·The Journal of Burn Care & Rehabilitation·Robert L SheridanLesa Breault
Dec 1, 2005·Journal of Clinical Neuromuscular Disease·Mark B Bromberg
Jun 17, 2003·The Neurologist·John N Gaitanis, Frank W Drislane
Jul 31, 2008·Critical Care Medicine·Jeffrey J FongJohn W Devlin
Feb 4, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary E HartmanScott R Schulman
Aug 19, 2007·The Journal of Trauma·Daniel J RosenRaymond V Wedderburn
Sep 15, 2012·Journal of Paediatrics and Child Health·Yu-Tze Ng, Rama Maganti
Oct 31, 2009·Critical Care : the Official Journal of the Critical Care Forum·Russel J RobertsJohn W Devlin
Jul 30, 2004·Anesthesia and Analgesia·Kimberley E CulpBonnie L Milas
Jun 18, 2002·Journal of Neurosurgery·John M AbrahamsGrant P Sinson
Mar 22, 2014·Journal of Epilepsy Research·Woo Sub HwangDae-Won Seo
Apr 20, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·N LaquayG Orliaguet
Dec 17, 2005·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Arthur J Newman, Nora G Singer
Oct 5, 2006·Current Opinion in Anaesthesiology·M Chollet-Rivier, R L Chioléro
Oct 5, 2006·Current Opinion in Anaesthesiology·Robin J Bray
Jul 11, 2006·Current Opinion in Anaesthesiology·Axel FudickarPeter H Tonner
Sep 12, 2008·Current Opinion in Anaesthesiology·Luuk C OtterspoorOlaf L Cremer
May 26, 2001·Anesthesiology·A E BadrJ H Eichhorn
Jun 29, 2004·Anesthesiology·Joe S Funston, Donald S Prough
Jun 29, 2004·Anesthesiology·Bethanie K BurowDouglas L Packer
Jun 29, 2004·Anesthesiology·Jean-Corentin SalengrosLuc Barvais
May 5, 1999·Current Opinion in Neurology·B K Alldredge, D H Lowenstein
Mar 28, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vincenzo Fodale, Enza La Monaca
Jul 6, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M UcarR Dahlqvist
Jan 15, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Daniel San-juanAndrew J Cole
Apr 28, 2009·Clinical Neurology and Neurosurgery·Richard A Rison, David Y Ko

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