PMID: 12773066May 30, 2003Paper

Rhabdomyolysis causing AV blockade due to possible atorvastatin, esomeprazole, and clarithromycin interaction

The Annals of Pharmacotherapy
Brooke E SipeGordon H Bokhart

Abstract

To report rhabdomyolysis (RML) causing third-degree atrioventricular block secondary to a possible interaction between atorvastatin, esomeprazole, and clarithromycin. A 51-year-old white woman presented to the emergency department with severe weakness, near syncope, shortness of breath, and chest pain. On admission, her electrocardiogram demonstrated bradycardia (40 beats/min) and third-degree heart block. A creatine kinase (CK) level was >7000 U/L. Her medication history was significant for long-term use of atorvastatin (>1 y), a 6-week history of esomeprazole use, and three 500-mg doses of clarithromycin just prior to admission. Her symptoms of weakness, shortness of breath, and chest pain coincided with starting the esomeprazole. During her hospitalization, the woman required pacemaker placement and her CK continued to rise to >40,000 U/L. Screening for other causes of RML, such as thyrotoxicosis, infection, and immune or hepatic diseases, was negative. She gradually improved over a 26-day hospitalization. This is a case of RML resulting in third-degree atrioventricular blockade. An objective causality assessment of the adverse reaction via the Naranjo probability scale revealed a probable association with atorvastatin and a...Continue Reading

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Jul 1, 1997·The Annals of Pharmacotherapy·J W Grunden, K A Fisher
Aug 8, 1998·The New England Journal of Medicine·F WeilertP L Stokes
Jun 24, 2000·JAMA : the Journal of the American Medical Association·P S WangJ Avorn
Jul 6, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M UcarR Dahlqvist
Oct 3, 2000·Clinical Pharmacology and Therapeutics·A J SadequeA J Wood
Feb 24, 2001·The Annals of Pharmacotherapy·A J Lee, D S Maddix
Mar 17, 2001·British Journal of Pharmacology·K BogmanJ Drewe
Sep 28, 2001·The Annals of Pharmacotherapy·M A OmarT S Cox
Jan 5, 2002·Naunyn-Schmiedeberg's Archives of Pharmacology·C Pauli-MagnusM F Fromm
Feb 19, 2002·The Annals of Pharmacotherapy·Mohamed A Omar, James P Wilson
Mar 1, 2002·Muscle & Nerve·Jason D WarrenPhilip D Thompson
Mar 29, 2002·The Annals of Pharmacotherapy·Pramodini B Kale-PradhanWilliam T Sypula

❮ Previous
Next ❯

Citations

Oct 22, 2008·World Journal of Gastroenterology : WJG·Quan ZhouSu Zeng
Jan 23, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Beatrice A Golomb, Marcella A Evans
Jun 8, 2006·European Journal of Clinical Pharmacology·David W J Clark, Johanna Strandell
May 31, 2013·European Journal of Clinical Pharmacology·Amélie MarsotNicolas Simon
Oct 27, 2004·Expert Opinion on Drug Safety·Michael H Davidson
Mar 27, 2007·Pharmacotherapy·Espen Molden, Kirsti Svendsen Andersson
Mar 15, 2005·Toxicology Letters·David BalayssacFrançois Coudore
Jun 28, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tao Zhang
Jun 16, 2016·Texas Heart Institute Journal·Gabriel M Aisenberg, Herbert L Fred
Nov 14, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Scott J Duncan, Colin W Howden
Mar 3, 2005·The Annals of Pharmacotherapy·Ignazio GrattaglianoGiuseppe Palasciano
May 22, 2008·The Annals of Pharmacotherapy·Joaquín HinojosaMd Elvira Casterá
Dec 29, 2005·The Annals of Pharmacotherapy·Marco TuccoriMario Del Tacca
Feb 7, 2004·Pharmacoepidemiology and Drug Safety
Jun 6, 2018·Internal Medicine Journal·Wee Jie CheeRalph Junckerstorff
Jun 19, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Espen MoldenPia Braathen
Feb 16, 2006·Transplantation·Céline MoreauValérie Furlan
Oct 20, 2019·Basic & Clinical Pharmacology & Toxicology·Mette Marie Hougaard ChristensenAndreas James Thestrup Pedersen
Oct 26, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Kathlyn J RonaldsonIan W Boyd
Feb 8, 2019·Therapeutic Advances in Drug Safety·Thananan RattanachotphanitOnanong Waleekhachonloet
Jul 7, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alice Capogrosso SansoneMarco Tuccori

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Related Papers

British Journal of Clinical Pharmacology
Meret Martin-FacklamWalter Emil Haefeli
International Journal of Clinical Pharmacology and Therapeutics
U I SchwarzW Kirch
Naunyn-Schmiedeberg's Archives of Pharmacology
C Pauli-MagnusMartin F Fromm
The New England Journal of Medicine
Dirk TaubertJochem W van Werkum
© 2022 Meta ULC. All rights reserved