Abstract
Deceased patients with acute kidney injury (AKI) from rhabdomyolysis can be considered as potential kidney donors. We performed a retrospective chart review from January 2005 to January 2011 of three donors with AKI from rhabdomyolysis and the four recipients of the donated kidneys. Three donors had AKI from rhabdomyolysis as evidenced by elevated serum creatinine levels, myoglobinuria, and plasma creatinine kinase levels greater than five times the upper limit of normal. All grafts were maintained on pulsatile machine perfusion (MP) prior to transplantation. In one of the patients, serial venous perfusate myoglobin levels were measured from the donor kidney while on MP. Three of the four recipients had delayed graft function, but all had normalized creatinine function after 1 month. One recipient had a creatinine of 1.2 after 79 months, the longest documented follow-up of this kind. Although we measured venous perfusate myoglobin levels from one of the grafts, we found the levels to decrease with increasing time spent on MP. Potential donors with AKI secondary to rhabdomyolysis should not be restricted from the donor pool. MP may play a role in minimizing the effects of AKI in these types of donors.
References
May 1, 1991·Journal of Computer Assisted Tomography·P D Russ, M Dillingham
Nov 1, 1989·Urology·W C RehaJ J Pahira
Jan 1, 1982·Annual Review of Medicine·J P Knochel
May 20, 1999·Critical Care Clinics·P Visweswaran, J Guntupalli
Mar 7, 2000·Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)·J SzustL Cravero
Jun 30, 2001·Intensive Care Medicine·S G Holt, K P Moore
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·Ana L Huerta-AlardínPaul E Marik
Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jesse D ScholdHerwig-Ulf Meier-Kriesche
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L MatsuokaR Selby
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O ThomuschP Pisarski
Jan 2, 2007·Transplantation·Mysore S Anil KumarAparna Kumar
May 8, 2007·Journal of the American College of Surgeons·Robert J StrattaPatricia L Adams
Oct 3, 2007·Internal and Emergency Medicine·W H BagleyK H Shah
Dec 20, 2007·Transplantation·Meera BajwaSuphamai Bunnapradist
May 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K L MekeelK S Reddy
Oct 3, 2009·Clinical Chemistry·Karina Rodríguez-CapoteAdell El Sharif
Oct 28, 2009·Cryobiology·Michael J Taylor, Simona C Baicu
Nov 24, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Citations
Feb 12, 2013·Journal of the American College of Surgeons·Alan C FarneyRobert J Stratta
Feb 11, 2015·QJM : Monthly Journal of the Association of Physicians·T AliK Almeshari
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elissa Oliveira da FonsecaAgnes B Fogo
Apr 4, 2016·Human Pathology·Helen LiapisFred Silva
Mar 3, 2017·Transplantation·Chuan-Bao ChenXiao-Peng Yuan
Jun 1, 2017·Clinical Transplantation·Chuan-Bao ChenXiao-Shun He
Nov 18, 2014·Transplantation·Sarah LeykingMatthias Klingele
Nov 2, 2017·Clinical Transplantation·Usman KhalidMohamed A Ilham
Oct 15, 2018·Transplantation Proceedings·X ChenC Wang