Rhabdomyolysis

Disease-a-month : DM
Brian Michael I CabralEdgar V Lerma

Abstract

Rhabdomyolysis is caused by the breakdown and necrosis of muscle tissue and the release of intracellular content into the blood stream. There are multiple and diverse causes of rhabdomyolysis but central to the pathophysiology is the destruction of the sarcolemmal membrane and release of intracellular components into the systemic circulation. The clinical presentation may vary, ranging from an asymptomatic increase in serum levels of enzymes released from damaged muscles to worrisome conditions such as volume depletion, metabolic and electrolyte abnormalities, and acute kidney injury (AKI). The diagnosis is confirmed when the serum creatine kinase (CK) level is > 1000 U/L or at least 5x the upper limit of normal. Other important tests to request include serum myoglobin, urinalysis (to check for myoglobinuria), and a full metabolic panel including serum creatinine and electrolytes. Prompt recognition of rhabdomyolysis is important in order to allow for timely and appropriate treatment. A McMahon score, calculated on admission, of 6 or greater is predictive of AKI requiring renal replacement therapy. Treatment of the underlying cause of the muscle insult is the first component of rhabdomyolysis management. Early and aggressive fl...Continue Reading

Citations

Jan 30, 2021·Critical Care : the Official Journal of the Critical Care Forum·Christina ScharfInes Schroeder
Feb 11, 2021·Curēus·Valentin Y SkryabinDmitry A Sychev
Mar 26, 2021·Journal of Cellular and Molecular Medicine·Tianshi SunDongshan Zhang
Jun 22, 2021·Military Medical Research·Peng-Tao WangYan-Hua Gong
Jun 30, 2021·Diabetes & Metabolic Syndrome·Mahmoud NassarEben Kimball
Aug 8, 2021·International Journal of Molecular Sciences·József Balla, Abolfazl Zarjou
Apr 1, 2021·Medicine and Science in Sports and Exercise·Chao LiuXuefeng Sun
Dec 11, 2021·Expert Review of Proteomics·Paul DowlingKay Ohlendieck

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