Rhabdomyosarcoma arising in the hand or foot: a clinicopathologic analysis

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Dylan V MillerHolly Zhou

Abstract

Rhabdomyosarcomas (RMS) arising at different anatomic sites have distinct clinicopathologic features that affect prognosis and outcome. RMS arising in the extremities generally have a worse prognosis. Case reports and anecdotal experience suggests the possibility that RMS of the hand or foot (RMSHF) may behave even more aggressively than RMS elsewhere in the extremities. This study describes clinicopathologic features and outcome of RMSHF. Charts and pathologic material from RMSHF cases from institutional files over a 32-year interval were reviewed. Additional cases from published reports and series over a 42-year interval were identified by a MEDLINE search. Pertinent clinicopathologic features for each case were compiled. Survival analysis and other data from these patients were compared with previously reported statistics in the literature for RMS at other anatomic sites, including elsewhere in the extremities. Six patients from the institutional files and 46 from published reports were identified. A number of adverse prognostic indicators were observed in the majority of these patients including alveolar morphology (86%) and distant metastasis at presentation (63%). Despite the aggressive nature of these tumors, the majorit...Continue Reading

References

Dec 1, 1989·Cancer·F GhavimiP Exelby
Nov 1, 1985·The Journal of Hand Surgery·H O Adeyemi-DoroO Olude
May 1, 1986·Klinische Pädiatrie·D SchmidtJ Treuner
Dec 1, 1980·Cancer·C B HowarthC B Pratt
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·P A JohnstoneT F DeLaney
Feb 1, 1994·American Journal of Clinical Pathology·C P MinnitiL J Helman
Jan 1, 1994·Cancer·M P La QuagliaM F Brennan
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J A EpsteinR L Maas
Jun 1, 1996·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·K XarchasF D Burke
Feb 1, 1997·Skeletal Radiology·Y SuzukiY Tamakawa
May 1, 1997·Journal of Pediatric Surgery·E GrossC B Pratt
Jul 23, 1999·European Radiology·C PerletM Reiser
Aug 16, 2001·Annals of Surgery·N F EsnaolaS Singer
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·D AyalonH Werner
Jul 19, 2002·Cancer·Darren J LittleRobert S Benjamin

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Citations

Mar 8, 2008·Pediatric Radiology·Rick R Van RijnJohannes H M Merks
Sep 1, 2007·Journal of Children's Orthopaedics·Michela CasanovaAndrea Ferrari
Jan 30, 2013·Journal of Plastic Surgery and Hand Surgery·Nevra SeyhanNedim Savaci
Jul 11, 2006·Journal of Pediatric Hematology/oncology·Myriam Weyl Ben ArushOra Israel
Jan 26, 2018·Pediatric Radiology·Monika ScheerUNKNOWN Cooperative Weichteilsarkom Studiengruppe (CWS)
Oct 4, 2005·Pediatric Blood & Cancer·G SeifertG Henze
Jun 27, 2006·The Journal of Bone and Joint Surgery. British Volume·H J SiegelD R Kelly
Jul 7, 2009·Pediatric Hematology and Oncology·Michela CasanovaAndrea Ferrari
Mar 7, 2006·The Journal of Hand Surgery·Peter J BueckerHenry J Mankin

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