PMID: 9166338May 1, 1997Paper

Rhabdomyosarcoma treated with chemotherapy during the third trimester

Obstetrics and Gynecology
D MartinP Nicklaus

Abstract

Rhabdomyosarcoma is an aggressive tumor that is rarely found in pregnancy, and is usually treated with multiagent chemotherapy. Chemotherapy given during pregnancy is associated with several maternal-fetal complications, including risks for mutagenicity, myelosuppression, and fetal death. An 18-year-old woman had stage III facial rhabdomyosarcoma diagnosed early in the third trimester. She achieved clinical remission with multiagent chemotherapy given during pregnancy, with no fetal complications. Invasive rhabdomyosarcoma is biologically predisposed to metastasize, and in the absence of effective chemotherapy, most patients will develop sites of distant recurrence. Chemotherapy plays an important role as frontline treatment in pregnant women with rhabdomyosarcoma.

References

Oct 27, 1990·Lancet·P Chastagner, D Sommelet-Olive
Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·B R Prestidge, S S Donaldson
Feb 1, 1983·Cancer·R V LloydW H Knapper
Feb 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·T A CallenderA el-Naggar
Nov 1, 1994·American Journal of Obstetrics and Gynecology·M P O'DayI A Wilkins
Jan 1, 1994·Cancer·M P La QuagliaM F Brennan
Mar 1, 1993·Cancer·H M MaurerJ Herrmann

❮ Previous
Next ❯

Citations

Aug 23, 2011·Archives of Gynecology and Obstetrics·Friederike HoellenMichael K Bohlmann
Jul 20, 2011·Cancer Chemotherapy and Pharmacology·Olivier MirAxel Le Cesne
Jul 14, 2016·Journal of Advanced Research·George ZarkavelisNicholas Pavlidis
Nov 15, 2011·Pediatric Blood & Cancer·Meinolf SiepermannRüdiger Wessalowski
Aug 2, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Brady P SeligJohn J Mulvihill
Sep 24, 2005·Lupus·M E B ClowseM Petri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.