Rhabdomyosarcoma treatment and outcome at a multidisciplinary pediatric cancer center in Lebanon

Pediatric Hematology and Oncology
Maysaa SalmanRaya Saab

Abstract

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Outcome of patients treated on standard protocols, in a multidisciplinary cancer center setting outside of clinical trials, is not well reported. We reviewed characteristics and outcome of 23 pediatric patients treated at a single, multidisciplinary cancer center in Lebanon, between April 2002 and December 2010. Median follow-up was 41 months. The most commonly affected primary site was the head and neck (48%, n = 11). Nineteen tumors (82.6%) were of embryonal histology. Tumor size was ≥5 cm in eight (34.8%) patients. Sixteen patients (69.6%) had localized disease, and one (4.4%) had metastatic disease. Fifteen (65.2%) had Group III tumors. All patients received chemotherapy, for a duration ranging 21-51 weeks. Upfront surgical resection was performed in 10 patients (43.5%). Eighteen patients (78.3%) received radiation therapy. The 5-year overall and disease-free survival rates were 83% and 64%, respectively. Relapse correlated with absence of surgery. Treatment of childhood RMS in a multidisciplinary cancer center in Lebanon results in similar survival to that in developed countries when similar protocols are applied. There was a higher incidence of loc...Continue Reading

References

Dec 23, 1999·The Journal of Biological Chemistry·S T KimM B Kastan
May 10, 2000·The Journal of Biological Chemistry·T O'NeillG A Rathbun
Jun 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K S BakerW M Crist
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M CristS S Donaldson
Nov 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K Scott BakerWilliam M Crist
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C BrenemanWilliam M Crist
Apr 3, 2004·Cancer Treatment Reviews·William H Meyer, Sheri L Spunt
May 4, 2005·Journal of Pediatric Surgery·David RodebergEugene Wiener
Apr 20, 2007·International Journal of Clinical Oncology·Hajime HosoiTohru Sugimoto
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Odile OberlinJames R Anderson
Mar 5, 2009·Apoptosis : an International Journal on Programmed Cell Death·Chao Lu, Wafik S El-Deiry
Apr 1, 2009·Expert Opinion on Drug Metabolism & Toxicology·Viet Hong PhanStephen J Clarke
Apr 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iyad SultanAndrea Ferrari
Aug 19, 2009·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jeong A ParkHyo Seop Ahn
Sep 12, 2009·Pediatric Blood & Cancer·Laila HessissenBrahim El Khalil El Gueddari
Dec 10, 2009·International Journal of Radiation Biology·Penny Jeggo, Martin F Lavin
Aug 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A Yuriko MinnSarah S Donaldson
Sep 8, 2010·Current Oncology Reports·Winston W Huh, Stephen X Skapek
Feb 18, 2011·Pediatric Blood & Cancer·Smita Bhatia

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Citations

Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Wei-Ling ZhangTian Zhi
Oct 3, 2012·Pediatric Hematology and Oncology·Vikas DuaAnupam Sachdeva
Oct 7, 2017·Indian Pediatrics·Deepak BansalKatragadda Lakshmi Narasimha Rao

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