rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model

The Journal of Bone and Joint Surgery. American Volume
Howard SeehermanJohn Wozney

Abstract

Bone resorption preceding bone formation has been reported following the administration of recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered in an absorbable collagen sponge (ACS) in metaphyseal bone. This study characterizes treatment with rhBMP-2/ACS in metaphyseal bone with use of a nonhuman primate core-defect model. Unilateral proximal femoral core defects were treated with 360 microg of rhBMP-2/ACS or ACS alone or were left untreated in seven, five, and five adult male cynomolgus monkeys, respectively. Distal femoral core defects in seven of the above animals were treated with 360 microg of rhBMP-2/ACS in one limb and ACS alone in the contralateral limb. Retention of rhBMP-2 in the proximal part of the femora was determined with use of tracer amounts of (125)I-rhBMP-2 imaged with a gamma camera. The distal part of the femora was evaluated with in vivo computed tomography. Computed tomography and histological evaluation were performed on harvested segments in all animals at twenty-four weeks. The histological response in the proximal and distal parts of the femora containing core defects treated with 360 microg of rhBMP-2/ACS in one limb and ACS alone in the contralateral limb was evaluated at one, two, an...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E A WangP LaPan
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Nov 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M KanataniK Chihara
Sep 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D WelchX J Li
Apr 7, 1999·Acta Orthopaedica Scandinavica·C JeppssonP Aspenberg
Jul 29, 1999·The American Journal of Sports Medicine·S A RodeoR F Warren
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E AbeS C Manolagas
Aug 17, 2001·The Journal of Bone and Joint Surgery. American Volume·M L BouxseinJ M Wozney
Nov 20, 2001·The Journal of Bone and Joint Surgery. American Volume·K L Wong, G R Williams
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kazuishi KubotaKenji Wakabayashi
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C A LuppenM L Bouxsein
Sep 3, 2002·Spine·Howard SeehermanRebecca Li
Oct 24, 2002·Journal of Spinal Disorders & Techniques·J Kenneth BurkusThomas A Zdeblick
Dec 11, 2002·The Journal of Bone and Joint Surgery. American Volume·Shunmugam GovenderUNKNOWN BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R H LiH J Seeherman
Dec 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D R SumnerJ M Wozney
Feb 7, 2004·Acta Orthopaedica Scandinavica·Magnus TägilPer Aspenberg
Aug 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Margaret A McGeeCarol Toth
Oct 27, 2004·Journal of Biomedical Materials Research. Part a·Kjeld SøballeJoan E Bechtold
Jun 3, 2005·The Journal of Bone and Joint Surgery. American Volume·J Kenneth BurkusMichael C Longley
Jun 7, 2005·Cytokine & Growth Factor Reviews·Howard Seeherman, John M Wozney
Jan 5, 2006·The Journal of Bone and Joint Surgery. American Volume·Howard SeehermanJohn M Wozney
Jun 9, 2006·Journal of Spinal Disorders & Techniques·Stephen M Hansen, Rick C Sasso
Jun 17, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H-P HsuM Spector
Jul 5, 2006·The Journal of Bone and Joint Surgery. American Volume·Howard J SeehermanJohn M Wozney
Oct 6, 2006·Journal of Spinal Disorders & Techniques·John W McClellanNancy Fullmer
Oct 22, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Susan L SchaeferMark D Markel

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Citations

Dec 1, 2012·Archives of Orthopaedic and Trauma Surgery·Angad MalhotraWilliam R Walsh
Jul 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marc Baud'huinPeter I Croucher
Dec 4, 2012·Arthritis Research & Therapy·Mandeep S Virk, Jay R Lieberman
Mar 29, 2014·Tissue Engineering. Part a·Angad MalhotraWilliam R Walsh
Mar 22, 2012·Advanced Drug Delivery Reviews·William J King, Paul H Krebsbach
Jun 9, 2015·Bone·Gonzalo Sánchez-DuffhuesPeter Ten Dijke
Jun 6, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mohammad Reza ZarrinkalamRobert J Moore
May 24, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stavros ThomopoulosRichard H Gelberman
Mar 5, 2016·Expert Opinion on Investigational Drugs·Michail E KlontzasEleftherios Tsiridis
Apr 22, 2016·Tissue Engineering. Part a·Ri Youn KimSoon Jung Hwang
Nov 18, 2016·The Journal of Bone and Joint Surgery. American Volume·X FuC L Song
Oct 4, 2012·The Journal of Bone and Joint Surgery. American Volume·Howard J SeehermanJohn M Wozney
Mar 30, 2013·Journal of Dental Research·C G WilsonR T Franceschi
Apr 1, 2018·Journal of Tissue Engineering and Regenerative Medicine·Maurits G L OlthofLichun Lu
Apr 25, 2018·Journal of Biomedical Materials Research. Part a·Shirin ToosiJavad Behravan
Oct 5, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rasmus CleemannJorgen Baas
Jun 2, 2018·Tissue Engineering. Part a·Aurimas ŠirkaLars Lidgren
Aug 30, 2018·Physiological Reviews·Jonathan W Lowery, Vicki Rosen
Jun 8, 2018·Journal of Pediatric Orthopedics. Part B·Nithin KesireddyNabil A Ebraheim
May 22, 2019·Journal of Biomedical Materials Research. Part a·Ram AlluriJay R Lieberman
Apr 11, 2012·The Journal of Bone and Joint Surgery. American Volume·Harry K W Kim
Nov 20, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer A McKenzieMegan L Killian

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