RhCl3 ·3H2 O-Catalyzed C7-Selective C-H Carbonylation of Indolines with CO and Alcohols

Organic Letters
Rongrong DuLei Yang

Abstract

An attractive method for the synthesis of indoline-7-carboxylates through RhCl3-catalyzed C-H carbonylation of indolines with CO and alcohols was developed. The copper-based oxidant and removable pyrimidyl directing group played important roles in achieving high-level yields of the title products. Based on control experiments, a possible catalytic cycle was proposed.

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Citations

Jun 11, 2020·Organic & Biomolecular Chemistry·Yaqi ShiYangjie Wu

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