RhCp*Cl₂]₂-catalyzed directed N-Boc amidation of arenes "on water"

Organic Letters
Md Ashif AliHongjian Lu

Abstract

Rhodium(III) catalysis "on water" is effective for directed C-H amidation of arenes. The catalytic process is promoted by OH groups present on the hydrophobic water surface and is inefficient in all (most) common organic solvents investigated so far. In the presence of easily prepared tert-butyl 2,4-dinitrophenoxycarbamate, a new and stable nitrene source, the "on water" reaction can efficiently provide the desired N-Boc-aminated products with good functional group tolerance.

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Citations

Jan 5, 2017·Chemical Reviews·Yoonsu ParkSukbok Chang
Feb 7, 2018·Chemistry : a European Journal·Fernando FumagalliLutz Ackermann
Apr 7, 2018·Organic & Biomolecular Chemistry·Daria V VorobyevaSergey N Osipov
Jul 24, 2018·Chemical Society Reviews·Carlo SambiagioMichael Schnürch
Feb 12, 2020·Chemistry : a European Journal·Yi WangYuanhua Wang
Feb 15, 2020·Chemistry : a European Journal·Taku Kitanosono, Shū Kobayashi

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