PMID: 9169563Jun 1, 1997Paper

Rhenium-188 hydroxyethylidene diphosphonate: a new generator-produced radiotherapeutic drug of potential value for the treatment of bone metastases

European Journal of Nuclear Medicine
W Y LinM G Stabin

Abstract

The search for an ideal radioisotope for systemic radiotherapy continues. As a generator-produced radioisotope emitting both beta and gamma rays and having a short physical half-life of 16.9 h, rhenium-188 is a very good potential candidate for systemic radiotherapy. In this study, we labeled hydroxyethylidene diphosphonate (HEDP) with 188Re and analyzed the biodistribution and bone uptake following intravenous injection in rats to assess its potential for clinical use. The rats were injected with approximately 14.8 MBq (0.4 mCi) 188Re-HEDP in a volume of 0.1 ml intravenously and then sacrificed at 1 h, 24 h, or 48 h (four rats at each time). Samples (about 0.1 g) of lung, liver, kidney, spleen, testis, muscle, stool, and bone (thoracic vertebra) were taken and weighed carefully. In addition, a 1-ml sample of blood was drawn from the heart and 1 ml of urine was taken from the urinary bladder immediately after killing. Tissue concentrations were calculated and expressed as percent injected dose per gram or per milliliter (% ID/g or ml). Bone lesions were created in the right tibial bone in three rabbits to calculate the lesion to normal uptake ratio (L/N ratio). The biodistribution data showed that the radioactivity in the bone ...Continue Reading

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Citations

Apr 2, 2002·Annals of Nuclear Medicine·Makoto ShigematsuHironobu Ochi
Feb 13, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Amal A El-Mabhouh, John R Mercer
Nov 19, 2003·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Eva Sailerova, Mervyn W Billinghurst
Oct 12, 2001·Clinical Nuclear Medicine·S LiX Zheng
Feb 16, 2006·Nuclear Medicine Communications·Bieke Lambert, John M H de Klerk
Mar 26, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Marnix G E H LamBernard A Zonnenberg
Feb 24, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·L García-SalinasJ Azorin-Nieto
Jan 17, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rogier LangeHarry Hendrikse
Aug 14, 2003·British Journal of Cancer·K LiepeJ Kotzerke
Sep 11, 2018·Medical Physics·Abner D SoaresAlessandro Facure

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