Rhenium-188 labelled meso-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl] porphyrin for targeted radiotherapy: preliminary biological evaluation in mice

European Journal of Nuclear Medicine and Molecular Imaging
Zhi-yun JiaShun-zhong Luo

Abstract

This study focusses on a promising carrier system for therapeutic and imaging purposes using meso-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl] porphyrin (T(3,4)CPP). To assess its potential for clinical use, we labelled T(3,4)CPP with (188)Re and analysed some kinetic biodistribution parameters after intravenous injection in mice. T(3,4)CPP was synthesized and labelled with (188)Re. Normal Kunming (KM) mice and melanoma- or hepatoma-bearing BALB/c nude mice were injected intravenously with 5.55 MBq (188)Re-labelled T(3,4)CPP and sacrificed at 0.5, 2, 4, and 24 h and 8, and 24 h, respectively. The (188)Re-T(3,4)CPP yield was more than 95% with specific activity 16.9 GBq (mol)(-1), and Vitamin C (VC) could increase its stability in vitro. In normal KM mice, (188)Re-T(3,4)CPP had fast blood clearance (approximately 99%, 24 h postinjection), low retention in the vital organs and hepatotropic characteristics. In nude mice, more than 4.4 and 6.1% uptake per gram of tumour (%ID g(-1)) at 8 h postinjection was in melanoma and hepatoma, respectively; this remained as high levels after 24 h as 4.6 and 6.5%, respectively. At 8 h, the tumour/blood and tumour/muscle (T/M) ratios in melanomas and hepatoma bearing mice were 7.3, 13,and 7.0, 2...Continue Reading

References

Nov 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·G Jori
Sep 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·H W StraussK Linder
Aug 26, 1998·Cancer Letters·Y ShibataS Nakajima
Mar 30, 1999·Nuclear Medicine and Biology·M R PillaiS Jurisson
Sep 22, 2001·Nuclear Medicine Communications·S BanerjeeM R Pillai
Sep 28, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S MurugesaA M Samuel
Sep 5, 2002·Journal of Photochemistry and Photobiology. B, Biology·S MurugesanO P D Noronha
Aug 22, 2003·Organic & Biomolecular Chemistry·Alexandrine MaravalBernard Meunier
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Jae Min Jeong, June-Key Chung
Jul 1, 1948·Proceedings of the Society for Experimental Biology and Medicine·F H J FIGGEL O J MANGANIELLO

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Citations

Oct 20, 2012·Theranostics·Yumiao Zhang, Jonathan F Lovell
Dec 26, 2012·Nuclear Medicine and Biology·Frederic ZollerFrank Rösch
Oct 29, 2015·Chemical Communications : Chem Comm·Jan Paulo T ZaragozaDavid P Goldberg
Jan 25, 2018·Pharmaceuticals·Fransiska KurniawanDaryono Hadi Tjahjono
Mar 19, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Pedro M SantosMaria Filomena Botelho

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