Jan 24, 2017

Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

Chemical Communications : Chem Comm
Chung Ying ChanPeter J Barnard

Abstract

A series of [Re(i)L(CO)3]+complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.

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  • References14
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Citations

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Amines
Methane
Complex (molecular entity)
Carbene, 13C-labeled
Plaque, Amyloid
Immunofluorescence Microscopy
BAG3
Alzheimer's Disease
Optical Imaging

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