Rheologic properties of sinonasal mucus in patients with chronic sinusitis

American Journal of Rhinology & Allergy
David M SaitoSteven D Pletcher

Abstract

Mucociliary clearance is impaired in chronic rhinosinusitis (CRS). Clearance of sinonasal secretions is influenced by its rheological properties. The purpose of this study was to describe the rheological properties of sinonasal mucus in patients with CRS and correlate them with disease severity. Twenty-three adult subjects with CRS underwent collection of sinonasal secretions. Samples were analyzed using the AR2000 cone and plate rheometer (TA Instruments, New Castle, DE) to determine the dynamic viscosity and elasticity. These properties were used to calculate mucus clearance indices. All patients completed the Sinonasal Outcome Test (SNOT-20). Recent sinus computed tomography (CT) scans were electronically reviewed and scored according to the Lund-McKay staging system. The mean dynamic elasticity and viscosity of sinus mucus at 1 Hz were 78.24 +/- 103.4 Pa and 22.09 +/- 29.62 Pa, respectively. The mean elasticity and viscosity values at 10 Hz were 118.9 +/- 155.5 Pa and 32.36 +/- 45.58 Pa, respectively. Three indices of disease severity (SNOT-20 score, Lund-McKay score, and nasal polyps) correlated with increased mucus viscoelasticity and/or worsened mucociliary clearance indices (MCIs). This study establishes the range of rh...Continue Reading

References

Jan 1, 1990·The American Review of Respiratory Disease·Y MajimaY Sakakura
Jul 1, 1983·Acta Oto-laryngologica·Y SakakuraY Miyoshi
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Aug 16, 2008·American Journal of Rhinology·Gilead BergerKoby Pitaro

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Citations

Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Jul 10, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Seong Ho ChoPhilippe Gevaert
Jul 12, 2011·Biomacromolecules·Catherine Taylor Nordgård, Kurt I Draget
Jun 29, 2017·International Forum of Allergy & Rhinology·Tim HardcastleRichard Douglas
Oct 8, 2019·International Forum of Allergy & Rhinology·Ludovic de GaboryLaurence Bordenave
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou

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