PMID: 9432021Jan 31, 1998Paper

Rheological analysis of the formation of rosettes by red blood cells parasitized by Plasmodium falciparum

British Journal of Haematology
Y ChuG B Nash

Abstract

Red blood cells infected by mature malarial parasites of the species Plasmodium falciparum can adhere to non-parasitized red cells (rosetting) and also to endothelial cells (cytoadhesion). To investigate how the circulation might influence rosetting, we studied formation of rosettes in cell suspensions sheared in a cone-and-plate viscometer, and the ability of flowing non-parasitized cells to bind to parasitized cells already adherent to a surface. After rosettes of strain R29 had been disrupted with fucoidan, they reformed slowly under stationary conditions but more rapidly in suspensions sheared at low stress (about 0.1-0.2 Pa). Strain Malayan Camp gave a lower rosetting frequency which actually increased at low shear. Increasing shear stress was associated with reduction in rosette formation, although rosetting occurred at >1 Pa, suggesting that rosettes could form in the systemic circulation. Rosetting inhibited adhesion of flowing parasitized cells to immobilized platelets (which express the cytoadhesion receptor CD36), as evidenced by increased adhesion after disruption of rosettes. The de-rosetted adherent cells parasitized by R29 supported only a low level of rosetting when non-parasitized cells were flowed over them at...Continue Reading

Citations

Jun 3, 2008·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·O Mercereau-PuijalonI Vigan-Womas
Apr 4, 2009·PLoS Computational Biology·Jakob M A MauritzVirgilio L Lew
Jul 19, 2012·PLoS Pathogens·Inès Vigan-WomasOdile Mercereau-Puijalon
Mar 24, 1999·Current Opinion in Hematology·D A Andrews, P S Low
Mar 25, 2020·Biomicrofluidics·Anna Martina JöttenChristoph Westerhausen

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