Rheological characterization of bioadhesive binary polymeric systems designed as platforms for drug delivery implants

Biomacromolecules
Gavin P Andrews, D S Jones

Abstract

This study describes the formulation and characterization of binary interactive polymeric systems, designed as platforms for improved drug delivery to mucosal sites. Binary interactive systems were manufactured containing hydroxyethylcellulose (HEC; 1-5% w/w) and polycarbophil (PC; 1-5% w/w) at pH 7, and their rheological (flow and dynamic), mechanical, and mucoadhesive properties were characterized, both before and after dilution with phosphate buffered saline (designed to mimic dilution by biological fluids). Physical interactions between HEC and PC were confirmed by the observed rheological synergy. Within the binary interactive systems increasing polymer concentration increased the storage modulus (G'), loss modulus (G' '), dynamic viscosity (eta'), hardness, compressibility, consistency, and mucoadhesion yet decreased the loss tangent. This was attributed to enhanced entanglements and interactions between adjacent polymer chains. Dilution with PBS altered the above properties; however, the binary interactive systems, particularly those containing higher concentrations of HEC, still exhibited predominantly elastic properties (high G', low tan delta). In light of this, it is suggested that the rheological and mucoadhesive pr...Continue Reading

References

May 1, 1995·Biomaterials·I G Needleman, F C Smales
Apr 1, 1997·Pharmaceutical Research·D S JonesA F Brown
Feb 26, 1998·Journal of Clinical Periodontology·I G NeedlemanF C Smales
May 8, 1999·The British Journal of Dermatology·C VenteC Neumann
Jun 11, 1999·Contraception·D H Owen, D F Katz
May 29, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·D S JonesC R Irwin
Mar 19, 2002·International Journal of Pharmaceutics·T Sanz TabernerJosé Vicente Herráez
Jun 28, 2002·International Journal of Pharmaceutics·Jung Yun ChangChong-Kook Kim
Aug 2, 2003·Cancer Letters·Zhi WangStanley M Shapshay
Jan 11, 2005·Critical Reviews in Therapeutic Drug Carrier Systems·John D Smart

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Citations

Aug 24, 2013·International Journal of Pharmaceutics·Sara M HanningNatalie J Medlicott
May 2, 2014·AAPS PharmSciTech·Satheesh PodarallaGita N Shankar
Jul 7, 2011·Expert Opinion on Drug Delivery·Tao YuGavin P Andrews
Nov 23, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Sabrina Barbosa De Souza FerreiraMarcos Luciano Bruschi
Mar 1, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Prem N GuptaR Karl Malcolm
Jul 6, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·D PliszczakP Lantéri
Sep 1, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carmen Rodriguez-TenreiroCarmen Alvarez-Lorenzo
Sep 9, 2011·The Journal of Pharmacy and Pharmacology·Esra BalogluDavid S Jones
Sep 3, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Andresa Aparecida BerrettaGustavo Henrique Goldman
Feb 22, 2012·Journal of Colloid and Interface Science·Wei ZhangTianzhuang Wang
Aug 19, 2010·Pharmaceutical Development and Technology·Esra BalogluTamer Guneri
Oct 29, 2013·Pharmaceutical Development and Technology·M Keshavarz, B Kaffashi
Jun 13, 2014·Molecular Pharmaceutics·Rita López-CebralAlejandro Sanchez
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Preeti PandeyHarendra S Parekh
May 11, 2018·Journal of Cosmetic Dermatology·Bilge ErenÖzgen Özer
Apr 3, 2020·Scientific Reports·Do Young ParkByung Hyune Choi
Apr 11, 2019·Polymers·Jéssica Bassi da SilvaMarcos Luciano Bruschi
Dec 31, 2019·Beilstein Journal of Nanotechnology·Sabrina Barbosa de Souza FerreiraMarcos Luciano Bruschi
Feb 1, 2008·Accounts of Chemical Research·Steven L Suib

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