Rheological characterization of new thermosensitive hydrogels formed by chitosan, glycerophosphate, and phosphorylated β-cyclodextrin

Carbohydrate Polymers
Carlos Alberto Ramírez BarragánEzequiel Delgado

Abstract

A novel thermosensitive hydrogel consisting of phosphorylated β-cyclodextrin (βCD-PH), β-cyclodextrin (βCD) and chitosan was prepared by embedding βCD and βCD-PH, into the well-studied chitosan/αβ-glycerophosphate system (CS/αβGP). The relevance of this work is the use of βCD-PH to partially substitute αβGP as the gelling agent. The role of βCD and βCD-PH on the rheological properties of hydrogels, gelation time, and gelation temperature were investigated. The gelation time for all the samples (CS/αβGP, CS/αβGP/βCD, and CS/αβGP/βCD-PH) was less than a minute at 37 °C, which is suitable for biomedical applications. The gelation temperature for hydrogel CS/αβGP/βCD-PH increased linearly with the addition of βCD-PH within the interval 31.8-37.3 °C, at ratios CS:βCD-PH of 1:0.5, 1:1, 1:1.5 and 1:2 (w/w). The hydrogel thus obtained has potential applications in dual drug delivery (hydrophilic and hydrophobic).

Citations

Jul 28, 2020·International Journal of Molecular Sciences·Roxana PopescuLăcrămioara Popa
Jan 1, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lorena Garcia-Del RioMariana Landin
Jan 29, 2021·International Journal of Biological Macromolecules·Dongying ZhangSidong Li

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