Rheopheresis for sudden sensorineural hearing loss

Atherosclerosis. Supplements
Reinhard KlingelRalph Mösges

Abstract

Patients suffering from sudden sensorineural hearing loss (SSHL), especially those with hearing impairment refractory to infusion therapy, need new therapeutic options. Fibrinogen-LDL-apheresis, covering Rheopheresis and HELP-apheresis for the indication of SSHL, proved to be an effective treatment option within the therapeutic armamentarium for SSHL in two randomized controlled trials including each more than 200 patients, and has also been shown to be an effective treatment option for patients refractory to the first line standard treatment. Fibrinogen-LDL-apheresis effects an immediate pulsed reduction of plasma viscosity as well as whole blood viscosity, hypothesized to lead to a sustained microcirculatory recovery, thus improving the natural course of acute microcirculatory impairment significantly. The solid body of evidence provided by investigations on fibrinogen-LDL-apheresis in recent years has been recognized by German SSHL guidelines, proposing fibrinogen-lowering treatments like this as part of a multimodality approach. Superiority of fibrinogen-LDL-apheresis over established first line standard treatments could not been shown in general. In consequence, no regular reimbursement by health insurances is available, i...Continue Reading

References

Jul 25, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Reinhard KlingelBritta Göhlen
Jul 31, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Reinhard KlingelErnst Küstner
Oct 16, 2007·The Journal of Biological Chemistry·Lavanya RajagopalanWilliam E Brownell

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Citations

Jun 21, 2016·Journal of Clinical Apheresis
Dec 29, 2020·Laryngoscope Investigative Otolaryngology·Masoud MohammadiAbdolhalim Rajabi
Nov 30, 2010·Acta otorrinolaringológica española·Guillermo PlazaUNKNOWN Asociación Madrileña de ORL

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