PMID: 108596Feb 1, 1979

Rhesus monkey (Macaca mulatta) model in genetic toxicology mitomycin C clastogenicity in germ cells

Mutation Research
G FicsorS M Fry


The value of rhesus monkeys (Macaca mulatta) as a genetic toxicology model is limited by their scarcity, expense, and impracticality of progeny testing. However, in some special circumstances, e.g., accidental exposure of humans to potential mutagens, rhesus monkeys or other primates may provide a superior animal model to help to cope with a difficult public health situation. Using the testis as a target organ we found that when primary spermatocytes were treated in pre-leptotene stage with 1 mg mitomycin C/kg body weight, the frequency of exchanges, fragments, sex-chromosome and autosomal univalents increased significantly at diakinesis-metaphase I. This response was absent in cells treated during diplotene, late pachytene or during spermatogonial stages. We suggested that animals should be evaluated not only for genetic toxicology parameters, but also toxicologically, histologically, behaviorally, for carcinogenesis and seminal cytology. Whenever possible, the animals should be recycled.


Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A J Wyrobek, W R Bruce
Jul 3, 1969·Annals of the New York Academy of Sciences·C C Smith


Jan 1, 1989·Environmental and Molecular Mutagenesis·W N ChoyS A Book

Related Concepts

Autosome Abnormalities
Medicinal Plants Testing, Preclinical
Genetic Techniques
Macaca mulatta
Y-Chromosome-Bearing Sperm

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