PMID: 9416487Jan 7, 1998Paper

Rheumatic Aschoff nodules revisited. II: Cytokine expression corroborates recently proposed sequential stages

Histopathology
W J FraserK Cooper

Abstract

A recent immunohistochemical analysis of the Aschoff lesions in rheumatic fever, combining immunohistochemical analysis with comparative morphology, permitted the division of the Aschoff nodules into three stages: (1) Aschoff nodule without admixed lymphocytes, (2) Aschoff nodules with a few T lymphocytes, and (3) Aschoff nodules containing many admixed lymphocytes of both B- and T-cell phenotype. It was postulated that the order of progression was from stage 1 with macrophages only, to accumulation of first T lymphocytes (stage 2) and then B lymphocytes (stage 3). This study was undertaken to determine the role and distribution of interleukin 1 (IL-1), interleukin 2 (IL-2) and tumour necrosis factor alpha (TNF alpha) in the various stages of the rheumatic Aschoff nodule to investigate our hypothesis on the progression of these nodules. Sixteen fresh valve specimens from patients with acute rheumatic fever undergoing valve surgery were obtained. Tissue sections from 14 specimens identified as containing Aschoff nodules were subjected to immunohistochemistry for (1) T and B lymphocytes, to stage the lesions according to our previously proposed criteria; (2) IL-1, IL-2 and TNF alpha; and (3) CD4 and CD8 to phenotype the T lymphoc...Continue Reading

Citations

Sep 29, 2011·Rheumatology International·Pedro Ming AzevedoLuiza Guilherme
Jul 10, 2003·Autoimmunity Reviews·Luiza Guilherme, Jorge Kalil
Jul 16, 2008·European Heart Journal·Bobby JohnPrashanthan Sanders
Jan 1, 2009·Journal of Innate Immunity·Mark T Quinn, Igor A Schepetkin
Dec 19, 2013·Journal of Cardiovascular Translational Research·Christine A KirvanMadeleine W Cunningham
Apr 22, 2015·Autoimmunity Reviews·William John MartinIan P Wicks
Dec 6, 2014·Frontiers in Pediatrics·Guilherme S SpinaFlávio Tarasoutchi
Jun 9, 2017·Pacing and Clinical Electrophysiology : PACE·Hongwu ChenMinglong Chen
Nov 25, 2017·Immunologic Research·Devinder Toor, Neha Sharma
Dec 1, 2013·Auto- Immunity Highlights·Luiza GuilhermeJorge Kalil

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