PMID: 5914764Oct 14, 1966

Rheumatic-like cardiac lesions in mice

W J Cromartie, J G Craddock


A single intraperitoneal injection of a sterile extract of sonically disrupted group A streptococcal cells induced an inflammatory process in the hearts of mice. The cardiac lesions, in terms of their distribution and histological features, are similar to the cardiac lesions of rheumatic fever.


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