Rheumatoid arthritis affects left ventricular mass: Systematic review and meta-analysis

European Journal of Internal Medicine
S CorraoFrancesco Perticone

Abstract

Cardiovascular disease represents one of the most important extra-articular causes of morbidity and mortality in patients with rheumatoid arthritis (RA). Evidences showed that several cardiac structures can be affected during the course of the disease as well as abnormalities of left ventricular diastolic filling. Contrasting data are available about left ventricular mass (LVM) involvement in patients asymptomatic for cardiovascular disease. The purpose of this systematic review and meta-analysis is to summarize the effects of RA on LVM in rheumatoid arthritis patients without cardiovascular disease. A systematic research of the current case-control studies was conducted in Medline on November 20th, 2013. Studies were included if data of measurements of LVM were reported. The pooled mean effect size estimate was calculated according to methods described by Hedges and Olkin. Sixteen eligible studies were included in this meta-analysis. RA determines an increase of absolute and indexed LVM compared with control patients [standardized mean difference (95% CI): 0.41(0.15-0.66) and 0.47(0.32-0.62), respectively]. On the contrary, posterior wall thickness did not show a significant RA effect. Finally, a significant positive effect of...Continue Reading

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Citations

Jun 17, 2016·Current Cardiology Reports·Maha A Al-Mohaissen, Kwan-Leung Chan
May 11, 2019·Expert Opinion on Therapeutic Targets·Eloi Franco-TrepatRodolfo Gómez Bahamonde
Dec 6, 2019·Rheumatology International·George S MetsiosUNKNOWN IMPACT-RMD Consortium
Dec 18, 2019·Advances in Rheumatology·Punchong Hanvivadhanakul, Adisai Buakhamsri
Feb 10, 2020·The International Journal of Cardiovascular Imaging·L A BissellJ Andrews
Oct 8, 2020·International Journal of Rheumatic Diseases·Ender Özgün ÇakmakMehmet Engin Tezcan
Mar 16, 2021·International Journal of Rheumatic Diseases·Giovanni CioffiAlessandro Giollo
Sep 16, 2021·Arthritis & Rheumatology·Elizabeth ParkJoan M Bathon

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