Rheumatoid arthritis and aromatase inhibitors

Joint, Bone, Spine : Revue Du Rhumatisme
Ewa BertoliniDaniel Wendling

Abstract

Aromatase inhibitors are widely used for the treatment of estrogen receptor-positive breast cancer in postmenopausal women. Joint pain is a common side effect. We report three cases of rheumatoid arthritis with onset after the initiation of aromatase inhibitor therapy. All three patients had antibodies to cyclic citrullinated peptides and two had sicca syndrome. Few similar cases have been published. Although a chance occurrence cannot be ruled out, evidence from animal models suggests that aromatase inhibitors may trigger or reveal rheumatoid arthritis.

References

Sep 6, 2005·Arthritis and Rheumatism·David T Felson, Steven R Cummings
Mar 21, 2007·The Breast : Official Journal of the European Society of Mastology·Harold J Burstein
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leilani MoralesPatrick Neven
Sep 16, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Omer DizdarKadri Altundag

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Citations

Aug 21, 2013·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel WendlingXavier Pivot
Apr 2, 2014·Annals of the New York Academy of Sciences·Silvia CapellinoMaurizio Cutolo
Jul 15, 2015·BMC Medical Genomics·Travis J A CraddockGordon Broderick
May 27, 2016·International Journal of Immunopathology and Pharmacology·Fabio MascellaManuela Fantini
Oct 16, 2014·Health Care Management Science·Alexander ScherrerKarl-Heinz Küfer
Jan 11, 2012·International Journal of Immunopathology and Pharmacology·V BruzzeseG Zampa
Aug 13, 2020·International Journal of Molecular Sciences·Sara TentiLuigi Pirtoli

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