Rheumatoid arthritis and periodontitis - inflammatory and infectious connections. Review of the literature.

Journal of Oral Microbiology
G Rutger Persson

Abstract

An association between oral disease/periodontitis and rheumatoid arthritis (RA) has been considered since the early 1820s. The early treatment was tooth eradication. Epidemiological studies suggest that the prevalence of RA and periodontitis may be similar and about 5% of the population are aged 50 years or older. RA is considered as an autoimmune disease whereas periodontitis has an infectious etiology with a complex inflammatory response. Both diseases are chronic and may present with bursts of disease activity. Association studies have suggested odds ratios of having RA and periodontitis varying from 1.8:1 (95% CI: 1.0-3.2, NS) to 8:1 (95% CI: 2.9-22.1, p<0.001). Genetic factors are driving the host responses in both RA and periodontitis. Tumor necrosis factor-α, a proinflammatory cytokine, regulates a cascade of inflammatory events in both RA and periodontitis. Porphyromonas gingivalis is a common pathogen in periodontal infection. P. gingivalis has also been identified in synovial fluid. The specific abilities of P. gingivalis to citrullinate host peptides by proteolytic cleavage at Arg-X peptide bonds by arginine gingipains can induce autoimmune responses in RA through development of anticyclic citrullinated peptide antib...Continue Reading

References

Nov 1, 1989·Journal of Clinical Periodontology·J LindheS S Socransky
Jan 1, 1996·Clinical Microbiology Reviews·D N Fredricks, D A Relman
Oct 1, 1996·Periodontology 2000·G C Armitage
Jan 13, 2001·Toxicology· HänninenJ Laakso
Apr 5, 2001·Current Rheumatology Reports·J McBeth, A J Silman
Jul 17, 2001·Journal of Periodontology·F B MercadoP M Bartold
Oct 15, 2003·Arthritis and Rheumatism·Solbritt Rantapää-DahlqvistWalther J van Venrooij
Apr 7, 2005·Journal of Clinical Periodontology·Juliana RibeiroArthur B Novaes
Aug 26, 2006·Periodontology 2000·Bruce J PasterFloyd E Dewhirst
Mar 3, 2007·The New England Journal of Medicine·Maurizio S TonettiJohn Deanfield
May 15, 2007·Immunological Reviews·Peter A Nigrovic, David M Lee
Jun 7, 2007·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Mhd Khaldoun Al-KatmaAli D Askari
Aug 19, 2007·Journal of Periodontology·Roy C Page, Paul I Eke
Nov 6, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G J SeymourK Yamazaki
Feb 16, 2008·Clinical Rheumatology·Richard M van VugtBen A C Dijkmans
Apr 10, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Natalia NikolaitchoukInger Mattsby-Baltzer
Jun 7, 2008·Journal of Periodontology·N PischonJ Detert
Jul 19, 2008·International Journal of Paediatric Dentistry·Eva LeksellBritt Hedenberg-Magnusson
Aug 1, 2008·Arthritis and Rheumatism·Andrew KinlochPatrick J Venables
Aug 23, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H J MarttilaH Soini
Jan 17, 2009·AJNR. American Journal of Neuroradiology·K K OguzB Anlar
Jan 24, 2009·BMC Infectious Diseases·Rutger PerssonDavid Eschenbach
May 15, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ricardo Santiago GomezPaula Rocha Moreira
Jul 17, 2009·The British Journal of Nutrition·P C CalderJ Zhao
Oct 20, 2009·BMC Microbiology·Panos N PapapanouRyan T Demmer
Nov 26, 2009·Journal of Clinical Periodontology·Rita E Martinez-MartinezJuan Pablo Loyola-Rodríguez

❮ Previous
Next ❯

Citations

Jan 1, 2013·Rheumatology International·Etsuko MaeshimaWataru Sakamoto
Feb 5, 2014·Internal Medicine·Satoshi TakasakiToshiyuki Takahashi
Jan 25, 2014·Current Rheumatology Reports·Joanna KozielJan Potempa
Jul 6, 2014·International Journal of Inflammation·Animesh Singh, Sarah Karrar
Sep 4, 2014·Autoimmunity Reviews·Lazaros I SakkasChris D Platsoucas
Oct 12, 2014·Journal of Endodontics·Elisabetta CottiPaolo Usai
Sep 20, 2015·International Journal of Rheumatic Diseases·Pulukool SandhyaVinod Scaria
Jun 19, 2013·Clinical Oral Implants Research·Stefan RenvertGösta Rutger Persson
Mar 28, 2013·Geriatrics & Gerontology International·Rupali Agnihotri, Sumit Gaur
Nov 18, 2014·Journal of Periodontal Research·M SağlamR Sütçü
Jun 14, 2016·Oxidative Medicine and Cellular Longevity·Alexander A Andreev-AndrievskiyAlexander N Lukashev
Jul 6, 2016·Clinical Reviews in Allergy & Immunology·Steven R Binder, Christine M Litwin
Nov 5, 2016·Journal of Translational Medicine·Kaja ErikssonTülay Yucel-Lindberg
Apr 22, 2017·Periodontology 2000·Gösta Rutger Persson
Mar 26, 2013·Journal of Dental Research·S KaurP M Bartold
Apr 2, 2014·Infection and Immunity·Eva A V MoelantsPaul Proost
Jul 4, 2015·The Open Dentistry Journal·Caio V G Roman-TorresRicardo E A S Diniz
May 11, 2019·Journal of Clinical Medicine·Kaja ErikssonTülay Yucel-Lindberg
Oct 28, 2019·Journal of Clinical Medicine·Drago LorenzoParvizi Javad
Mar 4, 2015·Archives of Disease in Childhood·Camille AupiaisMathie Lorrot

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
genetic modification
ESR
PCR
ELISA

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.