PMID: 9175933May 1, 1997Paper

Rheumatoid arthritis: autoreactive T cells recognising a novel 68k autoantigen

Annals of the Rheumatic Diseases
S BlässE M Schneider

Abstract

A 68k autoantigen has been identified by specific antibodies from patients with rheumatoid arthritis (RA). This study considered whether or not this antigen is a target for T cells and thus may play a part in T cell mediated immunopathology of active RA. The 68k antigen was isolated and used in a nitrocellulose bound form to stimulate T cells. Proliferation of T lymphocytes of peripheral blood as well as synovial fluid was measured. Peripheral blood T cells specifically proliferating against the 68k antigen were detected in 19 of 27 patients with RA (70%). For T cells isolated from peripheral blood, proliferation peaked on day 10. When T cells were isolated from actively inflamed synovial fluid, the proliferation kinetics shifted to a peak on day 3. Blockade of HLA class II antigens resulted in an increase of proliferation in the case of HLA-DP. Applying HLA-DP specific antibodies capable of inhibiting antigen presentation mediated by this molecule, T cells of 17 of 27 RA patients (63%) proliferated to a higher extent than with the 68k antigen alone. The phenomenon that an increased proliferation occurred upon blockade of a particular HLA class II family member was also demonstrated for DQ and DR: the 68k antigen likewise stimu...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·N A Mitchison
Jul 1, 1992·Immunology Today·M E DorfM Collins
Apr 1, 1992·Immunology Today·B R BloomB Diamond
Jan 1, 1992·Annual Review of Immunology·B R BloomP Salgame
Jun 1, 1989·British Journal of Rheumatology·T D Cooke, R A Scudamore
Nov 1, 1986·Human Immunology·G PawelecP Wernet
Dec 1, 1986·Immunological Reviews·I R Cohen
Jan 1, 1984·The Journal of Clinical Investigation·J HoloshitzI R Cohen
May 1, 1995·Annals of the Rheumatic Diseases·S BlässM Schwochau
Aug 1, 1994·The Journal of Experimental Medicine·E MichaëlssonR Holmdahl

❮ Previous
Next ❯

Citations

May 14, 1999·Arthritis and Rheumatism·S BlässG R Burmester
Jan 22, 2000·Arthritis and Rheumatism·G A SchellekensW J van Venrooij
Oct 19, 2000·Arthritis and Rheumatism·A BrunsF Hiepe
Dec 8, 2010·Proteomics. Clinical Applications·Laura GiustiStefano Bombardieri
Oct 27, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D Mewar, A G Wilson
Apr 7, 2017·Folia medica·Maria H KazakovaVictoria S Sarafian
Jan 1, 2000·Arthritis and Rheumatism·S BlässG R Burmester
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iain B McInnesWilliam Harnett
Jun 8, 2006·The Journal of the American Academy of Orthopaedic Surgeons·Reuben GobezieThomas S Thornhill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.