Rheumatoid arthritis is sufficient to cause atheromatosis but not arterial stiffness or hypertrophy in the absence of classical cardiovascular risk factors

Clinical Rheumatology
Aikaterini AridaPetros P Sfikakis

Abstract

Rheumatoid arthritis (RA) associates with increased cardiovascular disease (CVD) mortality thought to be due to accelerated arterial disease. Different components of arterial disease, namely, atheromatosis, arteriosclerosis, and arterial wall hypertrophy, are differentially affected by classical CVD risk factors, which are highly prevalent in these patients. We hypothesized that RA disease per se may also differentially affect these components. Of 267 consecutive RA patients, we selected specifically those who were free of established CVD and CVD risk factors (18 %); of them, 41 patients (36 women, 49 ± 13 years) could be matched effectively 1:1 for age and gender to healthy controls. Atheromatosis was assessed by the presence of carotid and/or femoral artery plaques, arteriosclerosis by pulse wave velocity and local wall elasticity, and arterial hypertrophy by intima-media thickness and cross-sectional area. More patients had atheromatic plaques than controls (29 vs. 12 %, p = 0.039), and multiarterial atheromatosis was more prevalent in RA (22 vs. 2 %, p = 0.026). Accelerated atheromatosis was not associated with rheumatoid factor, or anti-cyclic citrullinated peptide (CCP) autoantibody status. Plaque burden in patients with ...Continue Reading

References

Jun 1, 1997·Journal of Hypertension·E L Schiffrin, D Hayoz
Nov 26, 1999·Circulation·V Pasceri, E T Yeh
Dec 20, 2002·Nature·Peter Libby
Jul 2, 2003·Health and Quality of Life Outcomes·Bonnie Bruce, James F Fries
Mar 6, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology· YasminIan B Wilkinson
May 7, 2005·Expert Reviews in Molecular Medicine·Robert J StevensGeorge D Kitas
May 25, 2005·Hypertension·Mary J RomanJane E Salmon
Feb 24, 2006·Annals of Internal Medicine·Mary J RomanJane E Salmon
Jun 3, 2006·Stroke; a Journal of Cerebral Circulation·Guido Stoll, Martin Bendszus
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Feb 3, 2007·Clinical Rheumatology·Cecilia P ChungC Michael Stein
Mar 14, 2008·Seminars in Arthritis and Rheumatism·Carlos Gonzalez-JuanateyMiguel A Gonzalez-Gay
Oct 22, 2008·Annals of the Rheumatic Diseases·M WongB Kirkham
Dec 25, 2008·Journal of Women's Health·Laura L SchottMary Chester M Wasko
Jul 18, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Kimon S StamatelopoulosPetros P Sfikakis
Nov 4, 2009·Hypertension·Ian B WilkinsonJohn R Cockcroft
Jan 30, 2010·The Journal of Rheumatology·Hitomi KobayashiJoan M Bathon
Jun 18, 2010·Atherosclerosis·Kimon S StamatelopoulosPetros P Sfikakis
Sep 17, 2010·Internal and Emergency Medicine·Gianluigi MazzoccoliGianluigi Vendemiale
Sep 21, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Jean-Frédéric BoyerArnaud Constantin
Oct 5, 2010·Seminars in Arthritis and Rheumatism·Alper M van SijlMichael T Nurmohamed
Nov 27, 2010·Annals of the Rheumatic Diseases·George D Kitas, Sherine E Gabriel
Sep 20, 2011·Rheumatology·Aamer SandooGeorge D Kitas
Oct 4, 2011·Arthritis and Rheumatism·Jon T GilesJoan M Bathon
Mar 20, 2012·Annals of the Rheumatic Diseases·Juan Antonio Avina-ZubietaDiane Lacaille
Apr 20, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·G BamiasP P Sfikakis
Jun 15, 2014·Clinical Rheumatology·Dimitrios VassilopoulosChristodoulos Stefanadis

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Citations

Mar 22, 2018·Scandinavian Cardiovascular Journal : SCJ·Panagiota AnyfantiStella Douma
May 19, 2018·Rheumatology International·Małgorzata BiskupBożena Targońska-Stępniak
Jun 30, 2018·International Journal of Molecular Sciences·Aikaterini AridaPetros P Sfikakis
Jul 17, 2020·Current Hypertension Reports·P AnyfantiE Gkaliagkousi
Jan 28, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Eirini D BasdekiKalliopi Karatzi
Oct 26, 2021·Frontiers in Cardiovascular Medicine·Aikaterini AridaAntonios Chatzigeorgiou

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