PMID: 9186666Apr 5, 1997Paper

Rheumatoid factor autoantibodies in health and disease

Annals of the New York Academy of Sciences
R A MageedJ B Natvig

Abstract

Recent advances in molecular biological and human cell hybridization technology have significantly advanced the knowledge of mechanisms that underlie human rheumatoid factor (RF) production. These advances have provided insight into the etiopathogenesis of synovial inflammation and lymphocyte recruitment in rheumatoid arthritis (RA) joints. We have examined the mechanisms that lead to RF production in RA patients and those that regulate RF production in normals. The studies revealed structural features that distinguish RF produced in normals from those produced in RA synovial tissue. There are significant differences in the use of VL and VH genes between the two RF populations. Furthermore, IgV genes encoding synovial RF in RA have extensive evidence for nucleotide changes, leading to amino acid replacement in the complementarity determining regions (CDRs). In addition, RF produced in RA synovia show evidence for affinity maturation, isotype switch to IgG RF, and repertoire shift indicative of a continued recruitment of B cells. Together with computer modeling and crystallographic studies, our data suggest that the mechanisms that operate on RF selection in RA synovia are similar to immune responses to exogenous antigens. In co...Continue Reading

References

Jun 13, 1975·Annals of the New York Academy of Sciences·R M PopeM Mannik
Jan 1, 1992·Advances in Immunology·G J Nossal
Feb 1, 1991·The Journal of Experimental Medicine·E Roosnek, A Lanzavecchia
Feb 1, 1991·The Journal of Clinical Investigation·D A CarsonT J Kipps
Jan 1, 1990·The Journal of Experimental Medicine·M ShlomchikM Weigert
Dec 1, 1986·The Journal of Experimental Medicine·V RadouxD A Carson
Aug 2, 1987·Nature·M J ShlomchikM G Weigert
Feb 1, 1973·The Journal of Experimental Medicine·H G KunkelJ D Capra
Jan 1, 1974·The Journal of Experimental Medicine·H G KunkelJ D Capra
Dec 1, 1983·The Journal of Experimental Medicine·E K Bikoff
Jul 7, 1995·Annals of the New York Academy of Sciences·J B Natvig, A J Quayle
Jan 1, 1995·Scandinavian Journal of Rheumatology. Supplement·I MelchersH Eibel
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·M BørretzenK M Thompson
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·B PulendranG J Nossal
Aug 1, 1993·Immunology Today·C Berek, M Ziegner

❮ Previous
Next ❯

Citations

Dec 1, 2004·Kidney International·Rashad Barsoum
Aug 18, 2004·The Journal of Clinical Investigation·Hiroshi HataShimon Sakaguchi
Aug 9, 2006·Journal of Immunological Methods·M W HaymanJ L O'Donnell
Apr 25, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·T J SemradD L Robbins
Oct 28, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Bettina E HolmGunnar Houen
Jul 8, 2000·The British Journal of Nutrition·L CordainM S Hickey
Apr 10, 2002·Scandinavian Journal of Immunology·E YurievA B Edmundson
Mar 8, 2019·JCI Insight·Margaret H Chang, Peter A Nigrovic
Jun 15, 2019·PloS One·Sheila Lefoli Maibom-ThomsenGunnar Houen
Aug 28, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisMichael Maes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.