PMID: 376097May 1, 1979Paper

Rheumatoid factor in melanoma patients: alterations of humoral tumor immunity in vitro

Cancer
A E GiulianoD L Morton

Abstract

Rheumatoid factors (RF) were associated with alterations of antibody reactions to melanoma cells in vitro by two serologic assays. Removal of RF from melanoma patients' sera by absorption with Cohn's Fraction II coated latex particles enhanced seroreactivity in the Immune Adherence (IA) assay and diminished IgM detection by the Indirect Membrane Immunofluorescence (IMI) assay. The addition of serum with high titers of RF to these assay systems led to diminution of IA reactivity and enhancement of IgM detection by IMI. Since these factors are found in cancer patients' sera and can alter humoral immune reactions directed against antigens on the membranes of tumor cells, their presence should be recognized when performing assays with tumor target cells. RF may be of significance in the host-tumor relationship in vivo.

References

Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J J TwomeyC C Douglass
Jan 1, 1976·Annals of the New York Academy of Sciences·M G LewisL M Jerry
Feb 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S PyrhönenO Wager
Jan 1, 1966·Immunochemistry·R Heimer, F M Levin
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Nov 1, 1961·The Journal of Experimental Medicine·J L ABRUZZO, C L CHRISTIAN
May 1, 1970·Arthritis and Rheumatism·David Kaplan

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Citations

Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KiyosawaR H Purcell
Feb 7, 2021·Cancers·Alessio Ugolini, Marianna Nuti

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