PMID: 9662757Jul 15, 1998Paper

Rheumatoid hyperviscosity: analysis of a patient with intermediate complexes that block other autoantibodies and a review of the literature

Seminars in Arthritis and Rheumatism
R H ScofieldB T Kurien

Abstract

To report a patient who rheumatoid arthritis presented with hyperviscosity syndrome, analyze this patient's rheumatoid factor, and review the previously reported patients. Immunofluorescence for antinuclear antibodies, double immunodiffusion, enzyme-linked immunosorbent assay, and size exclusion chromatography were used before and after plasmapheresis to study the patient's rheumatoid hyperviscosity, and polyclonal gammopathy and references in identified papers was used to identify previously reported patients. Similar to several previous patients, this patient's sera contained both IgG and IgM rheumatoid factor and abundant intermediate complexes. Other autoantibodies, either from the patient or from other patients, were masked by rheumatoid factor or intermediate complexes from the reported patients sera. Rheumatic hyperviscosity is seen uncommonly, being reported in only 18 patients with rheumatoid arthritis and nine with other rheumatic illnesses. There are two mechanisms by which rheumatoid factor can lead to hyperviscosity, both of which require large amounts of rheumatoid factor. Rheumatoid hyperviscosity must be recognized because this life-threatening syndrome usually can be successfully treated with plasmapheresis acu...Continue Reading

References

May 1, 1977·The American Journal of the Medical Sciences·T FukasawaT Maekawa
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Citations

Jul 16, 2008·Autoimmunity Reviews·Biji T Kurien, R Hal Scofield
Aug 27, 2010·Clinical and Experimental Dermatology·S NodaS Sato
Jan 26, 2016·International Journal of Rheumatic Diseases·Gabriela Hernández-Molina, Paola Bermúdez-Bermejo
Nov 7, 2002·Critical Care Clinics·Ghulam SaydainSuhail Raoof
May 26, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·E J Lewis
Oct 31, 2019·The Journal of Applied Laboratory Medicine·Jennifer TaherVathany Kulasingam

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