Rheumatoid inflammation and joint destruction: cause and effect or parallel phenomena?

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J D WilliamsE C Huskisson

Abstract

Joint damage is a characteristic and important consequence of rheumatoid arthritis; it is usually considered to be a direct result of the inflammatory synovitis. This view implies that by treating actively the synovial inflammation subsequent joint damage will be reduced and the long-term outlook of patients with rheumatoid arthritis thus improved. However, there is relatively little clinical evidence that suppressing inflammation reduces rheumatoid joint damage. An alternative view is that the mechanisms causing inflammation and those leading to joint destruction are parallel processes related only indirectly. Considerable evidence supports such a concept. Clinical studies show radiological progression of the disease occurs despite improvements in measures of joint inflammation and a reduction in the levels of acute phase proteins. Damage can progress in either actively inflamed hot joints or cool swollen joints. Histopathologically the features of rheumatoid synovitis are non-specific, while the radiological pattern of joint damage is very characteristic. There is evidence that lymphocytic infiltration is not a poor prognostic finding, despite it being a typical feature of inflamed joints. Experimental studies also fail to sh...Continue Reading

References

Jul 1, 1977·Arthritis and Rheumatism·D E WoolleyJ M Evanson
Jun 13, 1975·Annals of the New York Academy of Sciences·D R RobinsonL Levine
Jun 1, 1977·Annals of the Rheumatic Diseases·A BrookM Corbett
Dec 1, 1975·Annals of the Rheumatic Diseases·G LoewiJ Reynolds
Jan 1, 1974·Annals of Internal Medicine·J W SiglerW R McCrum
Oct 22, 1970·The New England Journal of Medicine·UNKNOWN Cooperating Clinics Committee of the American Rheumatism Association
Oct 23, 1971·British Medical Journal·K D Muirden, K W Mills
Apr 5, 1980·British Medical Journal·V Wright, R Amos
Oct 1, 1984·The Journal of Pharmacy and Pharmacology·A D SedgwickD A Willoughby
Oct 27, 1983·The New England Journal of Medicine·L IannuzziI Kushner
Jun 1, 1984·Inflammation·H G Fassbender
Feb 1, 1984·Annals of the Rheumatic Diseases·D L ScottP A Bacon
Oct 8, 1982·JAMA : the Journal of the American Medical Association·D J McCarty, G F Carrera
Mar 1, 1981·Pflügers Archiv : European journal of physiology·W W WinderB N Premachandra
Jul 1, 1983·The American Journal of Cardiology·C M PrattM A Quinones
Apr 1, 1982·The Journal of Pathology·R W Jubb
Apr 1, 1981·Human Pathology·N S CooperJ L Rosenberger

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