Rheumatoid meningitis developed in patient with stable rheumatoid arthritis and myasthenia gravis-detailed analysis of intracranial inflammation using flow cytometry

Journal of Neuroinflammation
Miki OonoMakoto Matsui

Abstract

Rheumatoid meningitis (RM) is a rare disorder that often develops during a remission phase of rheumatoid arthritis (RA). This is the first study to demonstrate differences in regard to immunological disturbance between blood and cerebrospinal fluid (CSF) samples obtained from a patient with RM using flow cytometry. A 36-year-old woman with RA and generalized myasthenia gravis (MG) developed RM during a remission phase. Although both RA and MG were stable and well controlled, she noticed fever, headache, and transient sensory disturbance. Blood and CSF examination findings suggested aseptic meningitis, while brain magnetic resonance imaging revealed restricted portions of meningitis and associated cortical lesions, compatible with a diagnosis of RM. The dose of oral prednisolone was increased, which ameliorated the symptoms within 1 week along with improvement in CSF findings. This patient exhibited features of RM that were manifested in a manner independent of the activity of RA. An investigation of cellular immunity using CSF specimens with flow cytometry showed differences in regard to the pathogenesis of inflammation in the CSF as compared to outside of the central nervous system. In contrast to results obtained with paired ...Continue Reading

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Citations

Jun 11, 2020·Clinical Rheumatology·Milena Rodriguez AlvarezIsabel M McFarlane
Jul 12, 2019·Frontiers in Neurology·Mette Scheller NissenMorten Blaabjerg
Jun 24, 2021·Mediators of Inflammation·Rodolfo Kölliker-FrersFrancisco Capani
May 10, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Eduardo VillaCarlos Guevara
Jan 16, 2022·Clinical Rheumatology·Riccardo BixioOmbretta Viapiana

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Methods Mentioned

BETA
flow cytometry
biopsy
ESR

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