Rh(III)-Catalyzed [4 + 1]-Annulation of Azoxy Compounds with Alkynes: A Regioselective Approach to 2H-Indazoles

Organic Letters
Zhen LongJingsong You

Abstract

A rhodium-catalyzed regioselective C-H activation/cyclization of azoxy compounds with alkynes has been disclosed to construct a variety of 2H-indazoles. A [4 + 1]-cycloaddition rather than a normal [4 + 2] mode is observed in the process of cyclative capture along with an oxygen-atom transfer and a C≡C triple bond cleavage. This protocol features a broad substrate scope, a good functional group tolerance, and an exclusive regioselectivity.

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Citations

Feb 27, 2018·Organic & Biomolecular Chemistry·Rong ZhangXianhua Pan
Apr 13, 2018·Chemistry : a European Journal·Jens SchoeneMarc Nazaré

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