Rh(III)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using α-diazomalonates

Chemical Communications : Chem Comm
Jie ZhouWei Yi

Abstract

Here we report a new and mild Rh(III)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using α-diazomalonates. This reaction provided a straightforward way for installing both an α-quaternary carbon center and a free-OH moiety into the phenyl ring, thus giving access to useful 2-(2-hydroxyphenyl)-2-alkoxymalonates with good substrate/functional group tolerance.

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Citations

Jan 9, 2016·The Journal of Organic Chemistry·Debapratim DasRajarshi Samanta
Feb 26, 2016·Journal of the American Chemical Society·Christophe WerléAlois Fürstner
Oct 13, 2015·The Journal of Organic Chemistry·Juan Li, Zhiping Qiu
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Jan 28, 2017·Nature Communications·Qian WuJing Zhao
Apr 25, 2018·Chemistry : a European Journal·Yang Li, Silong Xu
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Nov 18, 2017·Journal of the American Chemical Society·Yunxiang WuBing Zhou
Jan 16, 2018·Journal of the American Chemical Society·Daniel J TindallAlois Fürstner

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