Rh(III)-Catalyzed C-H Cyanation of 2H-Indazole with N-Cyano-N-phenyl-p-toluenesulfonamide.

The Journal of Organic Chemistry
Jing LiMao-Ping Song

Abstract

A Rh(III)-catalyzed direct cyanation of 2H-indazoles with N-cyano-N-phenyl-p-toluenesulfonamide has been realized via a chelation-assisted strategy. The methodology enables regioselective access to various ortho-cyanated phenylindazoles in good yields with a broad substrate scope and good functional group compatibility. The obtained cyanated indazoles could further be converted into other value-added chemicals. Importantly, the current protocol is featured with several characteristics, including a novel cyanating agent, good regioselectivity, and operational convenience.

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